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Fc-modified exenatide-loaded nanoparticles for oral delivery to improve hypoglycemic effects in mice

Overview of attention for article published in Scientific Reports, January 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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1 blog
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78 Mendeley
Title
Fc-modified exenatide-loaded nanoparticles for oral delivery to improve hypoglycemic effects in mice
Published in
Scientific Reports, January 2018
DOI 10.1038/s41598-018-19170-y
Pubmed ID
Authors

Yanan Shi, Xinfeng Sun, Liping Zhang, Kaoxiang Sun, Keke Li, Youxin Li, Qiang Zhang

Abstract

To improve the oral efficiency of exenatide, we prepared polyethylene glycol-poly(lactic-co-glycolic acid) (PEG-PLGA) NPs modified with Fc (NPs-Fc) for exenatide oral delivery. Exenatide was encapsulated into the NPs by the w/o/w emulsion-solvent evaporation method. The particle size of the NPs-Fc was approximately 30 nm larger than that of the unmodified NPs with polydispersity indices in a narrow range (PDIs; PDI < 0.3) as detected by DLS, and the highest encapsulation efficiency of exenatide in the NPs was greater than 80%. Fc-conjugated NPs permeated Caco-2 cells faster and to a greater extent compared to unmodified NPs, as verified by CLSM and flow cytometry. Hypoglycemic effect studies demonstrated that oral administration of exenatide-loaded PEG-PLGA NPs modified by an Fc group extended the hypoglycemic effects compared with s.c. injection of the exenatide solution. Fluorescence-labeled NPs were used to investigate the effects of Fc targeting, and the results demonstrated that the NPs-Fc stayed in the gastrointestinal tract for a longer time in comparison with the unmodified NPs, as shown by the whole-body fluorescence images and fluorescence images of the dissected organs detected by in vivo imaging in live mice. Therefore, Fc-targeted nano-delivery systems show great promise for oral peptide/protein drug delivery.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 78 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 24%
Student > Master 14 18%
Student > Bachelor 7 9%
Researcher 6 8%
Student > Doctoral Student 5 6%
Other 8 10%
Unknown 19 24%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 23 29%
Biochemistry, Genetics and Molecular Biology 12 15%
Agricultural and Biological Sciences 4 5%
Chemistry 3 4%
Nursing and Health Professions 2 3%
Other 11 14%
Unknown 23 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2018.
All research outputs
#3,912,043
of 23,968,814 outputs
Outputs from Scientific Reports
#31,255
of 130,111 outputs
Outputs of similar age
#89,738
of 480,719 outputs
Outputs of similar age from Scientific Reports
#988
of 4,063 outputs
Altmetric has tracked 23,968,814 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 130,111 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.6. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 480,719 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 4,063 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.