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Social transmission and buffering of synaptic changes after stress

Overview of attention for article published in Nature Neuroscience, January 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#46 of 4,786)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Citations

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64 Dimensions

Readers on

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294 Mendeley
Title
Social transmission and buffering of synaptic changes after stress
Published in
Nature Neuroscience, January 2018
DOI 10.1038/s41593-017-0044-6
Pubmed ID
Authors

Toni-Lee Sterley, Dinara Baimoukhametova, Tamás Füzesi, Agnieszka A. Zurek, Nuria Daviu, Neilen P. Rasiah, David Rosenegger, Jaideep S. Bains

Abstract

Stress can trigger enduring changes in neural circuits and synapses. The behavioral and hormonal consequences of stress can also be transmitted to others, but whether this transmitted stress has similar effects on synapses is not known. We found that authentic stress and transmitted stress in mice primed paraventricular nucleus of the hypothalamus (PVN) corticotropin-releasing hormone (CRH) neurons, enabling the induction of metaplasticity at glutamate synapses. In female mice that were subjected to authentic stress, this metaplasticity was diminished following interactions with a naive partner. Transmission from the stressed subject to the naive partner required the activation of PVN CRH neurons in both subject and partner to drive and detect the release of a putative alarm pheromone from the stressed mouse. Finally, metaplasticity could be transmitted sequentially from the stressed subject to multiple partners. Our findings demonstrate that transmitted stress has the same lasting effects on glutamate synapses as authentic stress and reveal an unexpected role for PVN CRH neurons in transmitting distress signals among individuals.

Twitter Demographics

The data shown below were collected from the profiles of 397 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 294 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 294 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 58 20%
Student > Ph. D. Student 53 18%
Student > Master 47 16%
Student > Bachelor 43 15%
Student > Postgraduate 17 6%
Other 47 16%
Unknown 29 10%
Readers by discipline Count As %
Neuroscience 120 41%
Agricultural and Biological Sciences 52 18%
Psychology 21 7%
Biochemistry, Genetics and Molecular Biology 17 6%
Medicine and Dentistry 15 5%
Other 22 7%
Unknown 47 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 542. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2021.
All research outputs
#24,616
of 17,939,704 outputs
Outputs from Nature Neuroscience
#46
of 4,786 outputs
Outputs of similar age
#961
of 417,778 outputs
Outputs of similar age from Nature Neuroscience
#3
of 61 outputs
Altmetric has tracked 17,939,704 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,786 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 47.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 417,778 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.