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Evolutionary adaptation of plasmid-encoded enzymes for degrading nylon oligomers

Overview of attention for article published in Nature, November 1983
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)

Mentioned by

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2 patents
wikipedia
6 Wikipedia pages

Citations

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89 Dimensions

Readers on

mendeley
16 Mendeley
Title
Evolutionary adaptation of plasmid-encoded enzymes for degrading nylon oligomers
Published in
Nature, November 1983
DOI 10.1038/306203a0
Pubmed ID
Authors

Hirosuke Okada, Seiji Negoro, Hiroyuki Kimura, Shunichi Nakamura

Abstract

Flavobacterium sp. KI72 metabolizes 6-aminohexanoic acid cyclic dimer, a by-product of nylon manufacture, through two newly evolved enzymes, 6-aminohexanoic acid cyclic dimer hydrolase (EI) and 6-aminohexanoic acid linear oligomer hydrolase (EII). These enzymes are active towards man-made compounds, the cyclic dimer and linear oligomers of 6-aminohexanoic acid respectively, but not towards any of the natural amide bonds tested. The structural genes of EI (nylA) and EII (nylB) are encoded on pOAD2, one of three plasmids harboured in Flavobacterium sp. KI72. This plasmid contains two kinds of repeated sequence (RS-I and RS-II); one of the two RS-II sequences, RS-IIA, contains the nylB gene, while the other, RS-IIB, contains a homologous nylB' gene. From comparisons of the nucleotide sequences and gene products of the nylB and nylB' genes, we now conclude that EII enzyme is newly evolved by gene duplication followed by base substitutions on the same plasmid.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 38%
Student > Bachelor 2 13%
Student > Ph. D. Student 2 13%
Other 1 6%
Student > Doctoral Student 1 6%
Other 1 6%
Unknown 3 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 44%
Biochemistry, Genetics and Molecular Biology 5 31%
Linguistics 1 6%
Unknown 3 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2021.
All research outputs
#3,859,564
of 19,069,422 outputs
Outputs from Nature
#50,095
of 83,173 outputs
Outputs of similar age
#61,235
of 306,906 outputs
Outputs of similar age from Nature
#816
of 922 outputs
Altmetric has tracked 19,069,422 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,173 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 93.7. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,906 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 922 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.