Title |
Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
|
---|---|
Published in |
Nature Neuroscience, June 2005
|
DOI | 10.1038/nn1491 |
Pubmed ID | |
Authors |
Zhi-Li Huang, Wei-Min Qu, Naomi Eguchi, Jiang-Fan Chen, Michael A Schwarzschild, Bertil B Fredholm, Yoshihiro Urade, Osamu Hayaishi |
Abstract |
Caffeine, a component of tea, coffee and cola, induces wakefulness. It binds to adenosine A1 and A2A receptors as an antagonist, but the receptor subtype mediating caffeine-induced wakefulness remains unclear. Here we report that caffeine at 5, 10 and 15 mg kg(-1) increased wakefulness in both wild-type mice and A1 receptor knockout mice, but not in A2A receptor knockout mice. Thus, caffeine-induced wakefulness depends on adenosine A2A receptors. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 33% |
Turkey | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 377 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 5 | 1% |
United States | 3 | <1% |
Sweden | 2 | <1% |
France | 2 | <1% |
Brazil | 1 | <1% |
Austria | 1 | <1% |
China | 1 | <1% |
Indonesia | 1 | <1% |
Korea, Republic of | 1 | <1% |
Other | 1 | <1% |
Unknown | 359 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 73 | 19% |
Researcher | 58 | 15% |
Student > Bachelor | 58 | 15% |
Student > Master | 40 | 11% |
Professor | 16 | 4% |
Other | 57 | 15% |
Unknown | 75 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 85 | 23% |
Neuroscience | 69 | 18% |
Medicine and Dentistry | 45 | 12% |
Biochemistry, Genetics and Molecular Biology | 25 | 7% |
Psychology | 21 | 6% |
Other | 46 | 12% |
Unknown | 86 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2023.
All research outputs
#2,092,150
of 25,402,889 outputs
Outputs from Nature Neuroscience
#2,448
of 5,623 outputs
Outputs of similar age
#3,269
of 66,945 outputs
Outputs of similar age from Nature Neuroscience
#8
of 51 outputs
Altmetric has tracked 25,402,889 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,623 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 57.4. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 66,945 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.