Title |
Mitochondria as biosynthetic factories for cancer proliferation
|
---|---|
Published in |
Cancer & Metabolism, January 2015
|
DOI | 10.1186/s40170-015-0128-2 |
Pubmed ID | |
Authors |
Christopher S Ahn, Christian M Metallo |
Abstract |
Unchecked growth and proliferation is a hallmark of cancer, and numerous oncogenic mutations reprogram cellular metabolism to fuel these processes. As a central metabolic organelle, mitochondria execute critical biochemical functions for the synthesis of fundamental cellular components, including fatty acids, amino acids, and nucleotides. Despite the extensive interest in the glycolytic phenotype of many cancer cells, tumors contain fully functional mitochondria that support proliferation and survival. Furthermore, tumor cells commonly increase flux through one or more mitochondrial pathways, and pharmacological inhibition of mitochondrial metabolism is emerging as a potential therapeutic strategy in some cancers. Here, we review the biosynthetic roles of mitochondrial metabolism in tumors and highlight specific cancers where these processes are activated. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 50% |
Members of the public | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 2 | <1% |
Netherlands | 1 | <1% |
Chile | 1 | <1% |
Germany | 1 | <1% |
Korea, Republic of | 1 | <1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 346 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 79 | 22% |
Researcher | 53 | 15% |
Student > Master | 43 | 12% |
Student > Bachelor | 33 | 9% |
Student > Doctoral Student | 22 | 6% |
Other | 59 | 17% |
Unknown | 66 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 106 | 30% |
Agricultural and Biological Sciences | 73 | 21% |
Medicine and Dentistry | 35 | 10% |
Chemistry | 18 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 3% |
Other | 37 | 10% |
Unknown | 76 | 21% |