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Mitochondria as biosynthetic factories for cancer proliferation

Overview of attention for article published in Cancer & Metabolism, January 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#38 of 209)
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
1 blog
twitter
4 X users
facebook
1 Facebook page

Citations

dimensions_citation
288 Dimensions

Readers on

mendeley
355 Mendeley
Title
Mitochondria as biosynthetic factories for cancer proliferation
Published in
Cancer & Metabolism, January 2015
DOI 10.1186/s40170-015-0128-2
Pubmed ID
Authors

Christopher S Ahn, Christian M Metallo

Abstract

Unchecked growth and proliferation is a hallmark of cancer, and numerous oncogenic mutations reprogram cellular metabolism to fuel these processes. As a central metabolic organelle, mitochondria execute critical biochemical functions for the synthesis of fundamental cellular components, including fatty acids, amino acids, and nucleotides. Despite the extensive interest in the glycolytic phenotype of many cancer cells, tumors contain fully functional mitochondria that support proliferation and survival. Furthermore, tumor cells commonly increase flux through one or more mitochondrial pathways, and pharmacological inhibition of mitochondrial metabolism is emerging as a potential therapeutic strategy in some cancers. Here, we review the biosynthetic roles of mitochondrial metabolism in tumors and highlight specific cancers where these processes are activated.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 355 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 <1%
Netherlands 1 <1%
Chile 1 <1%
Germany 1 <1%
Korea, Republic of 1 <1%
United Kingdom 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 346 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 79 22%
Researcher 53 15%
Student > Master 43 12%
Student > Bachelor 33 9%
Student > Doctoral Student 22 6%
Other 59 17%
Unknown 66 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 106 30%
Agricultural and Biological Sciences 73 21%
Medicine and Dentistry 35 10%
Chemistry 18 5%
Pharmacology, Toxicology and Pharmaceutical Science 10 3%
Other 37 10%
Unknown 76 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2015.
All research outputs
#3,246,210
of 23,577,654 outputs
Outputs from Cancer & Metabolism
#38
of 209 outputs
Outputs of similar age
#47,680
of 355,697 outputs
Outputs of similar age from Cancer & Metabolism
#3
of 5 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 209 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 355,697 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.