| Title |
Sustained miRNA delivery from an injectable hydrogel promotes cardiomyocyte proliferation and functional regeneration after ischaemic injury
|
|---|---|
| Published in |
Nature Biomedical Engineering, November 2017
|
| DOI | 10.1038/s41551-017-0157-y |
| Pubmed ID | |
| Authors |
Leo L. Wang, Ying Liu, Jennifer J. Chung, Tao Wang, Ann C. Gaffey, Minmin Lu, Christina A. Cavanaugh, Su Zhou, Rahul Kanade, Pavan Atluri, Edward E. Morrisey, Jason A. Burdick |
| Abstract |
MicroRNA-based therapies that target cardiomyocyte proliferation have great potential for the treatment of myocardial infarction (MI). In previous work, we showed that the miR-302/367 cluster regulates cardiomyocyte proliferation in the prenatal and postnatal heart. Here, we describe the development and application of an injectable hyaluronic acid (HA) hydrogel for the local and sustained delivery of miR-302 mimics to the heart. We show that the miR-302 mimics released in vitro promoted cardiomyocyte proliferation over one week, and that a single injection of the hydrogel in the mouse heart led to local and sustained cardiomyocyte proliferation for two weeks. After MI, gel/miR-302 injection caused local clonal proliferation and increased cardiomyocyte numbers in the border zone of a Confetti mouse model. Gel/miR-302 further decreased cardiac end-diastolic (39%) and end-systolic (50%) volumes, and improved ejection fraction (32%) and fractional shortening (64%) four weeks after MI and injection, compared to controls. Our findings suggest that biomaterial-based miRNA delivery systems can lead to improved outcomes in cardiac regeneration. |
X Demographics
The data shown below were collected from the profiles of 196 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 51 | 26% |
| United Kingdom | 13 | 7% |
| Canada | 8 | 4% |
| France | 5 | 3% |
| Spain | 5 | 3% |
| Germany | 5 | 3% |
| Sweden | 4 | 2% |
| Italy | 4 | 2% |
| India | 3 | 2% |
| Other | 26 | 13% |
| Unknown | 72 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 114 | 58% |
| Scientists | 63 | 32% |
| Practitioners (doctors, other healthcare professionals) | 11 | 6% |
| Science communicators (journalists, bloggers, editors) | 8 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 254 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 254 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 60 | 24% |
| Student > Master | 33 | 13% |
| Researcher | 26 | 10% |
| Student > Bachelor | 26 | 10% |
| Student > Doctoral Student | 12 | 5% |
| Other | 29 | 11% |
| Unknown | 68 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 59 | 23% |
| Engineering | 40 | 16% |
| Medicine and Dentistry | 18 | 7% |
| Materials Science | 15 | 6% |
| Agricultural and Biological Sciences | 12 | 5% |
| Other | 37 | 15% |
| Unknown | 73 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 278. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2024.
All research outputs
#131,014
of 25,765,370 outputs
Outputs from Nature Biomedical Engineering
#66
of 1,153 outputs
Outputs of similar age
#2,829
of 449,000 outputs
Outputs of similar age from Nature Biomedical Engineering
#2
of 31 outputs
Altmetric has tracked 25,765,370 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,153 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 78.9. This one has done particularly well, scoring higher than 94% of its peers.
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We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.