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Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands

Overview of attention for article published in Scientific Reports, November 2017
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  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

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Title
Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands
Published in
Scientific Reports, November 2017
DOI 10.1038/s41598-017-16385-3
Pubmed ID
Authors

Roberta Fraioli, Penelope M. Tsimbouri, Leanne E. Fisher, Angela H. Nobbs, Bo Su, Stefanie Neubauer, Florian Rechenmacher, Horst Kessler, Maria-Pau Ginebra, Matthew J. Dalby, José M. Manero, Carlos Mas-Moruno

Abstract

Engineering the interface between biomaterials and tissues is important to increase implant lifetime and avoid failures and revision surgeries. Permanent devices should enhance attachment and differentiation of stem cells, responsible for injured tissue repair, and simultaneously discourage bacterial colonization; this represents a major challenge. To take first steps towards such a multifunctional surface we propose merging topographical and biochemical cues on the surface of a clinically relevant material such as titanium. In detail, our strategy combines antibacterial nanotopographical features with integrin selective synthetic ligands that can rescue the adhesive capacity of the surfaces and instruct mesenchymal stem cell (MSC) response. To this end, a smooth substrate and two different high aspect ratio topographies have been produced and coated either with an αvβ3-selective peptidomimetic, an α5β1-selective peptidomimetic, or an RGD/PHSRN peptidic molecule. Results showed that antibacterial effects of the substrates could be maintained when tested on pathogenic Pseudomonas aeruginosa. Further, functionalization increased MSC adhesion to the surfaces and the αvβ3-selective peptidomimetic-coated nanotopographies promoted osteogenesis. Such a dual physicochemical approach to achieve multifunctional surfaces represents a first step in the design of novel cell-instructive biomaterial surfaces.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 71 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 21%
Student > Master 12 17%
Researcher 7 10%
Student > Bachelor 7 10%
Student > Doctoral Student 4 6%
Other 10 14%
Unknown 16 23%
Readers by discipline Count As %
Engineering 10 14%
Materials Science 10 14%
Agricultural and Biological Sciences 8 11%
Medicine and Dentistry 7 10%
Biochemistry, Genetics and Molecular Biology 4 6%
Other 6 8%
Unknown 26 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2018.
All research outputs
#14,604,752
of 25,383,278 outputs
Outputs from Scientific Reports
#64,645
of 139,820 outputs
Outputs of similar age
#218,854
of 452,328 outputs
Outputs of similar age from Scientific Reports
#1,861
of 4,238 outputs
Altmetric has tracked 25,383,278 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 139,820 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 452,328 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 4,238 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.