| Title |
Cisplatin is retained in the cochlea indefinitely following chemotherapy
|
|---|---|
| Published in |
Nature Communications, November 2017
|
| DOI | 10.1038/s41467-017-01837-1 |
| Pubmed ID | |
| Authors |
Andrew M. Breglio, Aaron E. Rusheen, Eric D. Shide, Katharine A. Fernandez, Katie K. Spielbauer, Katherine M. McLachlin, Matthew D. Hall, Lauren Amable, Lisa L. Cunningham |
| Abstract |
Cisplatin chemotherapy causes permanent hearing loss in 40-80% of treated patients. It is unclear whether the cochlea has unique sensitivity to cisplatin or is exposed to higher levels of the drug. Here we use inductively coupled plasma mass spectrometry (ICP-MS) to examine cisplatin pharmacokinetics in the cochleae of mice and humans. In most organs cisplatin is detected within one hour after injection, and is eliminated over the following days to weeks. In contrast, the cochlea retains cisplatin for months to years after treatment in both mice and humans. Using laser ablation coupled to ICP-MS, we map cisplatin distribution within the human cochlea. Cisplatin accumulation is consistently high in the stria vascularis, the region of the cochlea that maintains the ionic composition of endolymph. Our results demonstrate long-term retention of cisplatin in the human cochlea, and they point to the stria vascularis as an important therapeutic target for preventing cisplatin ototoxicity. |
X Demographics
The data shown below were collected from the profiles of 67 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 23 | 34% |
| France | 4 | 6% |
| United Kingdom | 4 | 6% |
| Australia | 4 | 6% |
| Spain | 2 | 3% |
| Switzerland | 1 | 1% |
| Bulgaria | 1 | 1% |
| Brazil | 1 | 1% |
| Kenya | 1 | 1% |
| Other | 2 | 3% |
| Unknown | 24 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 32 | 48% |
| Scientists | 23 | 34% |
| Practitioners (doctors, other healthcare professionals) | 10 | 15% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 232 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 232 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 13% |
| Researcher | 28 | 12% |
| Student > Master | 26 | 11% |
| Student > Bachelor | 23 | 10% |
| Student > Doctoral Student | 16 | 7% |
| Other | 43 | 19% |
| Unknown | 66 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 43 | 19% |
| Biochemistry, Genetics and Molecular Biology | 28 | 12% |
| Chemistry | 21 | 9% |
| Neuroscience | 16 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 4% |
| Other | 37 | 16% |
| Unknown | 78 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 147. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2023.
All research outputs
#266,106
of 24,602,766 outputs
Outputs from Nature Communications
#3,912
of 53,091 outputs
Outputs of similar age
#6,048
of 447,808 outputs
Outputs of similar age from Nature Communications
#105
of 1,483 outputs
Altmetric has tracked 24,602,766 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 53,091 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.1. This one has done particularly well, scoring higher than 92% of its peers.
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We're also able to compare this research output to 1,483 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.