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Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole

Overview of attention for article published in Nature Communications, October 2014
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  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Average Attention Score compared to outputs of the same age and source

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198 Mendeley
Title
Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole
Published in
Nature Communications, October 2014
DOI 10.1038/ncomms6267
Pubmed ID
Authors

Midori Ohta, Tomoko Ashikawa, Yuka Nozaki, Hiroko Kozuka-Hata, Hidemasa Goto, Masaki Inagaki, Masaaki Oyama, Daiju Kitagawa

Abstract

Formation of one procentriole next to each pre-existing centriole is essential for centrosome duplication, robust bipolar spindle assembly and maintenance of genome integrity. However, the mechanisms maintaining strict control over centriole copy number are incompletely understood. Here we show that Plk4 and STIL, the key regulators of centriole formation, form a protein complex that provides a scaffold for recruiting HsSAS-6, a major component of the centriolar cartwheel, at the onset of procentriole formation. Furthermore, we demonstrate that phosphorylation of STIL by Plk4 facilitates the STIL/HsSAS-6 interaction and centriolar loading of HsSAS-6. We also provide evidence that negative feedback by centriolar STIL regulates bimodal centriolar distribution of Plk4 and seemingly restricts occurrence of procentriole formation to one site on each parental centriole. Overall, these findings suggest a mechanism whereby coordinated action of three critical factors ensures formation of a single procentriole per parental centriole.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 198 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 <1%
United States 1 <1%
Germany 1 <1%
Unknown 195 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 54 27%
Researcher 36 18%
Student > Master 18 9%
Student > Bachelor 17 9%
Student > Doctoral Student 12 6%
Other 17 9%
Unknown 44 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 65 33%
Biochemistry, Genetics and Molecular Biology 61 31%
Neuroscience 8 4%
Medicine and Dentistry 8 4%
Chemistry 5 3%
Other 3 2%
Unknown 48 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 October 2015.
All research outputs
#7,136,697
of 22,768,097 outputs
Outputs from Nature Communications
#36,060
of 46,898 outputs
Outputs of similar age
#80,350
of 260,971 outputs
Outputs of similar age from Nature Communications
#527
of 759 outputs
Altmetric has tracked 22,768,097 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 46,898 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.6. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,971 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 759 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.