| Title |
Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling
|
|---|---|
| Published in |
Nature, May 2010
|
| DOI | 10.1038/nature09121 |
| Pubmed ID | |
| Authors |
Su-Chang Lin, Yu-Chih Lo, Hao Wu |
| Abstract |
MyD88, IRAK4 and IRAK2 are critical signalling mediators of the TLR/IL1-R superfamily. Here we report the crystal structure of the MyD88-IRAK4-IRAK2 death domain (DD) complex, which surprisingly reveals a left-handed helical oligomer that consists of 6 MyD88, 4 IRAK4 and 4 IRAK2 DDs. Assembly of this helical signalling tower is hierarchical, in which MyD88 recruits IRAK4 and the MyD88-IRAK4 complex recruits the IRAK4 substrates IRAK2 or the related IRAK1. Formation of these Myddosome complexes brings the kinase domains of IRAKs into proximity for phosphorylation and activation. Composite binding sites are required for recruitment of the individual DDs in the complex, which are confirmed by mutagenesis and previously identified signalling mutations. Specificities in Myddosome formation are dictated by both molecular complementarity and correspondence of surface electrostatics. The MyD88-IRAK4-IRAK2 complex provides a template for Toll signalling in Drosophila and an elegant mechanism for versatile assembly and regulation of DD complexes in signal transduction. |
Mendeley readers
The data shown below were compiled from readership statistics for 629 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 2% |
| United Kingdom | 6 | <1% |
| Japan | 3 | <1% |
| Norway | 2 | <1% |
| Germany | 2 | <1% |
| Belgium | 2 | <1% |
| Denmark | 2 | <1% |
| India | 1 | <1% |
| Slovenia | 1 | <1% |
| Other | 4 | <1% |
| Unknown | 595 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 164 | 26% |
| Researcher | 105 | 17% |
| Student > Master | 80 | 13% |
| Student > Bachelor | 64 | 10% |
| Student > Doctoral Student | 31 | 5% |
| Other | 101 | 16% |
| Unknown | 84 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 212 | 34% |
| Biochemistry, Genetics and Molecular Biology | 123 | 20% |
| Immunology and Microbiology | 66 | 10% |
| Medicine and Dentistry | 60 | 10% |
| Chemistry | 22 | 3% |
| Other | 40 | 6% |
| Unknown | 106 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2024.
All research outputs
#1,599,488
of 23,556,846 outputs
Outputs from Nature
#38,021
of 92,598 outputs
Outputs of similar age
#5,254
of 95,915 outputs
Outputs of similar age from Nature
#173
of 576 outputs
Altmetric has tracked 23,556,846 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 92,598 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 100.5. This one has gotten more attention than average, scoring higher than 58% of its peers.
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We're also able to compare this research output to 576 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.