| Title |
Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)
|
|---|---|
| Published in |
Scientific Reports, October 2017
|
| DOI | 10.1038/s41598-017-13794-2 |
| Pubmed ID | |
| Authors |
Randall S. Prather, Kevin D. Wells, Kristin M. Whitworth, Maureen A. Kerrigan, Melissa S. Samuel, Alan Mileham, Luca N. Popescu, Raymond R. R. Rowland |
| Abstract |
After infection of the porcine dam at about 90 days of gestation, porcine reproductive and respiratory syndrome virus (PRRSV) crosses the placenta and begins to infect fetuses. Outcomes of include abortion, fetal death and respiratory disease in newborn piglets. CD163 is the receptor for the virus. In this study, CD163-positive fetuses, recovered between 109 days of gestation or 20 days after maternal infection, were completely protected from PRRSV in dams possessing a complete knockout of the CD163 receptor. The results demonstrate a practical means to eliminate PRRSV-associated reproductive disease, a major source of economic hardship to agriculture. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 47 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 17% |
| Student > Bachelor | 8 | 17% |
| Researcher | 6 | 13% |
| Student > Master | 4 | 9% |
| Student > Doctoral Student | 3 | 6% |
| Other | 4 | 9% |
| Unknown | 14 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 28% |
| Veterinary Science and Veterinary Medicine | 7 | 15% |
| Biochemistry, Genetics and Molecular Biology | 6 | 13% |
| Immunology and Microbiology | 1 | 2% |
| Economics, Econometrics and Finance | 1 | 2% |
| Other | 4 | 9% |
| Unknown | 15 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 79. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2019.
All research outputs
#461,551
of 23,006,268 outputs
Outputs from Scientific Reports
#5,202
of 124,252 outputs
Outputs of similar age
#10,941
of 326,544 outputs
Outputs of similar age from Scientific Reports
#217
of 4,882 outputs
Altmetric has tracked 23,006,268 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 124,252 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has done particularly well, scoring higher than 95% of its peers.
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We're also able to compare this research output to 4,882 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.