Title |
The structure and function of G-protein-coupled receptors
|
---|---|
Published in |
Nature, May 2009
|
DOI | 10.1038/nature08144 |
Pubmed ID | |
Authors |
Daniel M. Rosenbaum, Søren G. F. Rasmussen, Brian K. Kobilka |
Abstract |
G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 3,198 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 35 | 1% |
United Kingdom | 16 | <1% |
Germany | 13 | <1% |
Canada | 7 | <1% |
Denmark | 6 | <1% |
France | 5 | <1% |
Netherlands | 4 | <1% |
India | 4 | <1% |
Brazil | 3 | <1% |
Other | 38 | 1% |
Unknown | 3067 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 631 | 20% |
Student > Bachelor | 607 | 19% |
Student > Master | 443 | 14% |
Researcher | 366 | 11% |
Student > Doctoral Student | 125 | 4% |
Other | 365 | 11% |
Unknown | 661 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 789 | 25% |
Biochemistry, Genetics and Molecular Biology | 638 | 20% |
Chemistry | 312 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 219 | 7% |
Medicine and Dentistry | 176 | 6% |
Other | 355 | 11% |
Unknown | 709 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 69. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2024.
All research outputs
#549,626
of 23,565,002 outputs
Outputs from Nature
#23,441
of 92,619 outputs
Outputs of similar age
#1,214
of 98,472 outputs
Outputs of similar age from Nature
#31
of 531 outputs
Altmetric has tracked 23,565,002 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 92,619 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 100.5. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 98,472 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 531 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.