| Title |
Long-term metabolic risk for the metabolically healthy overweight/obese phenotype
|
|---|---|
| Published in |
International Journal of Obesity, September 2017
|
| DOI | 10.1038/ijo.2017.233 |
| Pubmed ID | |
| Authors |
AE Espinosa De Ycaza, D Donegan, M D Jensen |
| Abstract |
The clinical relevance of the metabolically healthy overweight/obese (MHO) phenotype is controversial and the relationships between weight change and the development of cardiometabolic risk factors is unknown. Therefore, we aim to: (1) Assess the long-term risk of developing one or more components of the metabolic syndrome in MHO adults compared with metabolically healthy normal weight (MHNW); (2) Evaluate risk of a composite of death, cardiovascular disease (CVD), and risk of developing type 2 diabetes between adults defined according to baseline body mass index and metabolic health. Retrospective cohort study of adults 18-65 years of age seen at our institution between 1998 and 2000 who lived in Olmsted County. Metabolically healthy was defined as the absence of all components of the metabolic syndrome (except for waist circumference). Main outcome was the development of metabolic risk factors. The secondary outcome was a composite of mortality, CVD and heart failure. Of the 18 070 individuals with complete data at baseline, 1805 (10%) were MHO (mean age 38±11 years) and 3047 were MHNW (mean age 35±11 years). After a median follow-up of 15 years, interquartile range 10-17, 80% of MHO vs 68% of MHNW developed at least one cardiometabolic risk factor (P<0.001). In multivariate analysis, MHO individuals who gained ⩾10% of their body weight were more likely to have developed metabolic complications compared to MHO individuals that did not gain weight (P=0.001 for 10-15%, P<0.001 for >15% weight gain). The risk for the secondary composite end point was similar between MHO and MHNW, number of events 218/1805 vs 217/3048 for MHO and MHNW, respectively, (hazard ratio: 1.16, 95% confidence interval: 0.96-1.40). MHO are more likely to develop metabolic complications than MHNW, especially if they gain weight.International Journal of Obesity advance online publication, 24 October 2017; doi:10.1038/ijo.2017.233. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 38% |
| United Kingdom | 2 | 15% |
| Canada | 2 | 15% |
| Burkina Faso | 1 | 8% |
| Zimbabwe | 1 | 8% |
| Spain | 1 | 8% |
| Unknown | 1 | 8% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 69% |
| Practitioners (doctors, other healthcare professionals) | 3 | 23% |
| Scientists | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 75 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 16% |
| Researcher | 9 | 12% |
| Student > Master | 8 | 11% |
| Other | 6 | 8% |
| Student > Doctoral Student | 5 | 7% |
| Other | 15 | 20% |
| Unknown | 20 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 33% |
| Nursing and Health Professions | 6 | 8% |
| Sports and Recreations | 4 | 5% |
| Immunology and Microbiology | 3 | 4% |
| Agricultural and Biological Sciences | 2 | 3% |
| Other | 10 | 13% |
| Unknown | 25 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2023.
All research outputs
#1,661,428
of 25,362,278 outputs
Outputs from International Journal of Obesity
#838
of 4,693 outputs
Outputs of similar age
#32,328
of 327,940 outputs
Outputs of similar age from International Journal of Obesity
#12
of 71 outputs
Altmetric has tracked 25,362,278 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,693 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.8. This one has done well, scoring higher than 82% of its peers.
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We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.