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Screening of Clock Gene Polymorphisms Demonstrates Association of a PER3 Polymorphism with Morningness–Eveningness Preference and Circadian Rhythm Sleep Disorder

Overview of attention for article published in Scientific Reports, September 2014
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

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2 news outlets
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12 X users

Citations

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108 Dimensions

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188 Mendeley
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1 CiteULike
Title
Screening of Clock Gene Polymorphisms Demonstrates Association of a PER3 Polymorphism with Morningness–Eveningness Preference and Circadian Rhythm Sleep Disorder
Published in
Scientific Reports, September 2014
DOI 10.1038/srep06309
Pubmed ID
Authors

Akiko Hida, Shingo Kitamura, Yasuko Katayose, Mie Kato, Hiroko Ono, Hiroshi Kadotani, Makoto Uchiyama, Takashi Ebisawa, Yuichi Inoue, Yuichi Kamei, Masako Okawa, Kiyohisa Takahashi, Kazuo Mishima

Abstract

A system of self-sustained biological clocks controls the 24-h rhythms of behavioral and physiological processes such as the sleep-wake cycle. The circadian clock system is regulated by transcriptional and translational negative feedback loops of multiple clock genes. Polymorphisms in circadian clock genes have been associated with morningness-eveningness (diurnal) preference, familial advanced sleep phase type (ASPT), and delayed sleep phase type (DSPT). We genotyped single-nucleotide polymorphisms in circadian clock genes in 182 DSPT individuals, 67 free-running type (FRT) individuals, and 925 controls. The clock gene polymorphisms were tested for associations with diurnal preference and circadian rhythm sleep disorder (CRSD) phenotypes. The PER3 polymorphism (rs228697) was significantly associated with diurnal preference and the FRT phenotype. The minor allele of rs228697 was more prevalent in evening types than in morning types (sex-adjusted odds ratio (OR), 2.483, Bonferroni-corrected P = 0.012) and in FRT individuals compared with the controls (age- and sex-adjusted OR, 2.021, permutated P = 0.017). Our findings support the notion that PER3 polymorphisms could be a potential genetic marker for an individual's circadian and sleep phenotypes.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 188 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Japan 1 <1%
Russia 1 <1%
Unknown 185 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 31 16%
Student > Bachelor 28 15%
Researcher 27 14%
Student > Master 15 8%
Student > Postgraduate 13 7%
Other 39 21%
Unknown 35 19%
Readers by discipline Count As %
Medicine and Dentistry 36 19%
Agricultural and Biological Sciences 30 16%
Biochemistry, Genetics and Molecular Biology 29 15%
Neuroscience 20 11%
Psychology 12 6%
Other 19 10%
Unknown 42 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2023.
All research outputs
#1,200,622
of 23,539,593 outputs
Outputs from Scientific Reports
#11,891
of 127,344 outputs
Outputs of similar age
#13,158
of 240,097 outputs
Outputs of similar age from Scientific Reports
#53
of 701 outputs
Altmetric has tracked 23,539,593 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 127,344 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.4. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,097 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 701 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.