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Two independent modes of chromatin organization revealed by cohesin removal

Overview of attention for article published in Nature, September 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

2 news outlets
1 blog
89 tweeters
1 Wikipedia page
1 Google+ user
1 research highlight platform


740 Dimensions

Readers on

1084 Mendeley
3 CiteULike
Two independent modes of chromatin organization revealed by cohesin removal
Published in
Nature, September 2017
DOI 10.1038/nature24281
Pubmed ID

Wibke Schwarzer, Nezar Abdennur, Anton Goloborodko, Aleksandra Pekowska, Geoffrey Fudenberg, Yann Loe-Mie, Nuno A Fonseca, Wolfgang Huber, Christian H. Haering, Leonid Mirny, Francois Spitz


Imaging and chromosome conformation capture studies have revealed several layers of chromosome organization, including segregation into megabase-sized active and inactive compartments, and partitioning into sub-megabase domains (TADs). It remains unclear, however, how these layers of organization form, interact with one another and influence genome function. Here we show that deletion of the cohesin-loading factor Nipbl in mouse liver leads to a marked reorganization of chromosomal folding. TADs and associated Hi-C peaks vanish globally, even in the absence of transcriptional changes. By contrast, compartmental segregation is preserved and even reinforced. Strikingly, the disappearance of TADs unmasks a finer compartment structure that accurately reflects the underlying epigenetic landscape. These observations demonstrate that the three-dimensional organization of the genome results from the interplay of two independent mechanisms: cohesin-independent segregation of the genome into fine-scale compartments, defined by chromatin state; and cohesin-dependent formation of TADs, possibly by loop extrusion, which helps to guide distant enhancers to their target genes.

Twitter Demographics

The data shown below were collected from the profiles of 89 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 1,084 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 4 <1%
Germany 1 <1%
Switzerland 1 <1%
Lithuania 1 <1%
Italy 1 <1%
Canada 1 <1%
United States 1 <1%
Unknown 1074 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 351 32%
Researcher 176 16%
Student > Bachelor 99 9%
Student > Master 95 9%
Student > Doctoral Student 54 5%
Other 122 11%
Unknown 187 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 484 45%
Agricultural and Biological Sciences 252 23%
Physics and Astronomy 39 4%
Medicine and Dentistry 27 2%
Computer Science 16 1%
Other 65 6%
Unknown 201 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 71. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2020.
All research outputs
of 21,626,295 outputs
Outputs from Nature
of 88,467 outputs
Outputs of similar age
of 296,736 outputs
Outputs of similar age from Nature
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Altmetric has tracked 21,626,295 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 88,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 97.8. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 296,736 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 898 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.