| Title |
Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
|
|---|---|
| Published in |
Oncogene, July 2007
|
| DOI | 10.1038/sj.onc.1210641 |
| Pubmed ID | |
| Authors |
A Preet, R K Ganju, J E Groopman |
| Abstract |
Delta(9)-Tetrahydrocannabinol (THC) is the primary cannabinoid of marijuana and has been shown to either potentiate or inhibit tumor growth, depending on the type of cancer and its pathogenesis. Little is known about the activity of cannabinoids like THC on epidermal growth factor receptor-overexpressing lung cancers, which are often highly aggressive and resistant to chemotherapy. In this study, we characterized the effects of THC on the EGF-induced growth and metastasis of human non-small cell lung cancer using the cell lines A549 and SW-1573 as in vitro models. We found that these cells express the cannabinoid receptors CB(1) and CB(2), known targets for THC action, and that THC inhibited EGF-induced growth, chemotaxis and chemoinvasion. Moreover, signaling studies indicated that THC may act by inhibiting the EGF-induced phosphorylation of ERK1/2, JNK1/2 and AKT. THC also induced the phosphorylation of focal adhesion kinase at tyrosine 397. Additionally, in in vivo studies in severe combined immunodeficient mice, there was significant inhibition of the subcutaneous tumor growth and lung metastasis of A549 cells in THC-treated animals as compared to vehicle-treated controls. Tumor samples from THC-treated animals revealed antiproliferative and antiangiogenic effects of THC. Our study suggests that cannabinoids like THC should be explored as novel therapeutic molecules in controlling the growth and metastasis of certain lung cancers. |
X Demographics
The data shown below were collected from the profiles of 110 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 27 | 25% |
| United Kingdom | 18 | 16% |
| Indonesia | 7 | 6% |
| Canada | 2 | 2% |
| Hong Kong | 1 | <1% |
| Cuba | 1 | <1% |
| Japan | 1 | <1% |
| Jamaica | 1 | <1% |
| Montenegro | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 50 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 103 | 94% |
| Practitioners (doctors, other healthcare professionals) | 4 | 4% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
| Scientists | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 185 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 3% |
| Spain | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 177 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 34 | 18% |
| Student > Ph. D. Student | 29 | 16% |
| Researcher | 21 | 11% |
| Student > Master | 21 | 11% |
| Other | 16 | 9% |
| Other | 27 | 15% |
| Unknown | 37 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 18% |
| Agricultural and Biological Sciences | 28 | 15% |
| Biochemistry, Genetics and Molecular Biology | 27 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 8% |
| Psychology | 9 | 5% |
| Other | 33 | 18% |
| Unknown | 40 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 252. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2023.
All research outputs
#148,304
of 25,584,565 outputs
Outputs from Oncogene
#16
of 11,145 outputs
Outputs of similar age
#162
of 79,469 outputs
Outputs of similar age from Oncogene
#2
of 113 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,145 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 79,469 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 113 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.