@ChemicalBiology @curiouswavefn Laura, what is wrong with this explanation? I was under the impression that only one enantiomer of thalidomide acts as a glue to degrade SALL4. These articles would seem to support that: https://t.co/MYZ0xnHdd2 and https://t
RT @Sciguy999: 60 Years After The Thalidomide Crisis, We Finally Understand What Went Wrong https://t.co/1SlLVBnMeP https://t.co/GZ9b2apE8D…
RT @Sciguy999: 60 Years After The Thalidomide Crisis, We Finally Understand What Went Wrong https://t.co/1SlLVBnMeP https://t.co/GZ9b2apE8D…
60 Years After The Thalidomide Crisis, We Finally Understand What Went Wrong https://t.co/1SlLVBnMeP https://t.co/GZ9b2apE8D https://t.co/FudbdN14HV ($$) https://t.co/tTWL81RFtQ ($$) #biochemistry #biology #thalidomide @jaybradner @eLife @cenmag @Biochemis
@curiouswavefn @eperlste @fraser_lab @rguha @DrAnneCarpenter @pwk2013 @neysanev Cereblon-thalidomide http://t.co/SAgItqAEFA
[Nature] Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to tha http://t.co/m2LxHVBTaq
Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs http://t.co/EPXMKE8wNC
サリドマイドがユビキチンリガーゼを活性化する構造的理解。あの催奇形性もこれが原因でしょうか。骨髄腫の治療も進みそう。日本発の研究が発展していくのはいいですね。http://t.co/Y6UBMcicg4
奈良先端大など、免疫調整薬の標的たんぱく質の3次元構造を解明:日刊工業新聞 http://t.co/lrzKtBMlNo サリドマイドの標的タンパク質「セレブロン」の三次元構造を解明 (nat struct mol biol原著)→ http://t.co/2cuZrOmitU
Crystal structure of CRBN bound to DDB1 and #Revlimid reported, which may help in novel drug design for #myeloma: http://t.co/FjpZL7D1lp.
Thalidomide paper by Lin: http://t.co/YDD3MIPrPS and competing paper in nsmb:http://t.co/JeqMrKuwck #fljcnlt
Crystal structure of CRBN bound to DDB1 and #Revlimid reported, which may help in novel drug design for #myeloma: http://t.co/FjpZL7D1lp.
Crystal structure of CRBN bound to DDB1 and #Revlimid reported, which may help in novel drug design for #myeloma: http://t.co/FjpZL7D1lp.
NSMBにもCRBN-サリドマイド誘導体複合体の結晶構造報告。こちらは東工大半田研(CRBNをサリドマイドの標的と同定したグループ)や奈良先端大箱嶋研の人が著者に。責任著者が属するのはサリドマイドやその誘導体を現在販売するセルジーン社。http://t.co/xNL07dKVBQ