Disease biomarkers and treatment methods related thereto Grant US-11785925-B2 United States of America 17 Oct 2023
Dihydrobenzimidazolones for medical treatment Grant US-11787802-B2 United States of America 17 Oct 2023
Cereblon binders for the degradation of ikaros Grant US-11753397-B2 United States of America 12 Sep 2023
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SYSTEMS AND METHODS OF SELECTING COMPOUNDS THAT INDUCE CONFORMATIONAL CHANGES IN MUTANT… Application WO-2023122726-A3 World Intellectual Property Organisation (WIPO) 17 Aug 2023
Methods for treating multiple myeloma and the use of companion biomarkers for 4-(4-(4-(((2… Grant US-11726080-B2 United States of America 15 Aug 2023
Isoindolinone and indazole compounds for the degradation of EGFR Grant US-11673902-B2 United States of America 13 Jun 2023
Glutarimide moiety based isoindolinone derivatives and use thereof Application KR-20230068335-A Republic of Korea 17 May 2023
Methods to induce targeted protein degradation through bifunctional molecules Grant US-11583586-B2 United States of America 21 Feb 2023
Compositions and methods for treating CDK4/6-mediated cancer Grant US-11541051-B2 United States of America 03 Jan 2023
Degraders and Degrons for targeted protein degradation Grant US-11524949-B2 United States of America 13 Dec 2022
Compositions and methods for treating EZH2-mediated cancer Grant US-11510920-B2 United States of America 29 Nov 2022
Serine threonine kinase (AKT) degradation / disruption compounds and methods of use Grant US-11472799-B2 United States of America 18 Oct 2022
Tau-protein targeting PROTACs and associated methods of use Grant US-11458123-B2 United States of America 04 Oct 2022
N/O-linked Degrons and Degronimers for protein degradation Grant US-11459335-B2 United States of America 04 Oct 2022
Methods for treating cancer and the use of biomarkers as a predictor of clinical… Grant US-11460471-B2 United States of America 04 Oct 2022
Methods of characterizing resistance to modulators of Cereblon Grant US-11459613-B2 United States of America 04 Oct 2022
Compositions and methods for inducing conformational changes in cereblon and other E3… Grant US-11419861-B2 United States of America 23 Aug 2022
Methods for screening cereblon modifying compounds Grant US-11402372-B2 United States of America 02 Aug 2022
Dihydrobenzimidazolones for medical treatment Grant US-11254672-B2 United States of America 22 Feb 2022
Piperidine-2,6-dione derivative and use thereof Grant US-11192878-B2 United States of America 07 Dec 2021
Spirocyclic degronimers for target protein degradation Grant US-11185592-B2 United States of America 30 Nov 2021
Methods of identifying a polypeptide target for degradation by a modulator of CRBN Grant US-11168345-B2 United States of America 09 Nov 2021
Bifunctional molecules for degradation of EGFR and methods of use Grant US-11161842-B2 United States of America 02 Nov 2021
Synthesis of small molecule histone deacetylase 6 degraders, compounds formed thereby… Grant US-11059815-B2 United States of America 13 Jul 2021
Methods to induce targeted protein degradation through bifunctional molecules Grant US-11059801-B2 United States of America 13 Jul 2021
Synthesis of small molecule histone deacetylase 6 degraders, compounds formed thereby… Grant US-11045458-B2 United States of America 29 Jun 2021
COMPOSITIONS AND METHODS FOR INDUCING CONFORMATIONAL CHANGES IN CEREBLON AND OTHER E3… Application EP-3827836-A1 European Patent Office 02 Jun 2021
Methods for treating multiple myeloma and the use of companion biomarkers for 4-(4-(4-(((2… Grant US-10969381-B2 United States of America 06 Apr 2021
Heterocyclic degronimers for target protein degradation Grant US-10905768-B1 United States of America 02 Feb 2021
C3-carbon linked glutarimide degronimers for target protein degradation Grant US-10849982-B2 United States of America 01 Dec 2020
Methods to induce targeted protein degradation through bifunctional molecules Grant US-10849980-B2 United States of America 01 Dec 2020
Compositions and methods for inducing conformational changes in cereblon and other E3… Grant US-10830762-B2 United States of America 10 Nov 2020
BIFUNCTIONAL COMPOUNDS COMPRISING APCIN-A AND THEIR USE IN THE TREATMENT OF CANCER Application WO-2020214555-A1 World Intellectual Property Organisation (WIPO) 22 Oct 2020
Compositions and methods for inducing conformational changes in cereblon and other E3… Grant US-10668057-B2 United States of America 02 Jun 2020
Methods to induce targeted protein degradation through bifunctional molecules Grant US-10669253-B2 United States of America 02 Jun 2020
Spirocyclic degronimers for target protein degradation Grant US-10660968-B2 United States of America 26 May 2020
Novel piperidine-2,6-dione derivatives and use thereof Application KR-20200054046-A Republic of Korea 19 May 2020
Heterocyclic degronimers for target protein degradation Grant US-10646575-B2 United States of America 12 May 2020
Methods for treating cancer and the use of biomarkers as a predictor of clinical… Grant US-10648983-B2 United States of America 12 May 2020
TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE Application WO-2020038415-A1 World Intellectual Property Organisation (WIPO) 27 Feb 2020
Methods to induce targeted protein degradation through bifunctional molecules Grant US-10464925-B2 United States of America 05 Nov 2019
Bifunctional molecules for degradation of EGFR and methods of use Grant US-10450310-B2 United States of America 22 Oct 2019
SERINE THREONINE KINASE (AKT) DEGRADATION / DISRUPTION COMPOUNDS AND METHODS OF USE Application WO-2019173516-A1 World Intellectual Property Organisation (WIPO) 12 Sep 2019
Targeted protein degradation using a mutant E3 ubiquitin ligase Application US-10239888-B2 United States of America 26 Mar 2019
Methods to induce targeted protein degradation through bifunctional molecules Application US-10125114-B2 United States of America 13 Nov 2018
SMALL MOLECULES Application WO-2018189554-A1 World Intellectual Property Organisation (WIPO) 18 Oct 2018
Compositions and methods for inducing conformational changes in cereblon and other E3… Grant US-10092555-B2 United States of America 09 Oct 2018
Methods for the treatment of cancer and inflammatory diseases using cereblon as a… Grant US-10047151-B2 United States of America 14 Aug 2018
Methods for determining drug efficacy using cereblon-associated proteins Grant US-9857359-B2 United States of America 02 Jan 2018
COMPOSITIONS AND METHODS FOR INDUCING CONFORMATIONAL CHANGES IN CEREBLON OTHER E3… Application EP-3160486-A4 European Patent Office 13 Dec 2017
METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES Application WO-2017024317-A3 World Intellectual Property Organisation (WIPO) 27 Apr 2017
Pharmaceutical composition containing core factor involved in proliferation and… Grant US-9611465-B2 United States of America 04 Apr 2017
Cereblon isoforms and their use as biomarkers for therapeutic treatment Grant US-9587281-B2 United States of America 07 Mar 2017
Methods for the treatment of cancer and inflammatory diseases using cereblon as a… Grant US-9365640-B2 United States of America 14 Jun 2016