| Title |
Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial
|
|---|---|
| Published in |
BMC Pharmacology and Toxicology, July 2014
|
| DOI | 10.1186/2050-6511-15-40 |
| Pubmed ID | |
| Authors |
Simone Azevedo de Zanette, Rafael Vercelino, Gabriela Laste, Joanna Ripoll Rozisky, André Schwertner, Caroline Buzzatti Machado, Fernando Xavier, Izabel Cristina Custódio de Souza, Alicia Deitos, Iraci L S Torres, Wolnei Caumo |
| Abstract |
Central disinhibition is a mechanism involved in the physiopathology of fibromyalgia. Melatonin can improve sleep quality, pain and pain threshold. We hypothesized that treatment with melatonin alone or in combination with amitriptyline would be superior to amitriptyline alone in modifying the endogenous pain-modulating system (PMS) as quantified by conditional pain modulation (CPM), and this change in CPM could be associated with serum brain-derived neurotrophic factor (BDNF). We also tested whether melatonin improves the clinical symptoms of pain, pain threshold and sleep quality. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 11% |
| United States | 2 | 11% |
| United Kingdom | 1 | 5% |
| Japan | 1 | 5% |
| Switzerland | 1 | 5% |
| Netherlands | 1 | 5% |
| Unknown | 11 | 58% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 53% |
| Practitioners (doctors, other healthcare professionals) | 5 | 26% |
| Scientists | 4 | 21% |
Mendeley readers
The data shown below were compiled from readership statistics for 221 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | <1% |
| Colombia | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 217 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 32 | 14% |
| Student > Doctoral Student | 22 | 10% |
| Student > Ph. D. Student | 21 | 10% |
| Researcher | 20 | 9% |
| Student > Bachelor | 18 | 8% |
| Other | 48 | 22% |
| Unknown | 60 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 64 | 29% |
| Nursing and Health Professions | 23 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 7% |
| Agricultural and Biological Sciences | 13 | 6% |
| Neuroscience | 11 | 5% |
| Other | 23 | 10% |
| Unknown | 72 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 38. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2023.
All research outputs
#1,076,302
of 25,372,398 outputs
Outputs from BMC Pharmacology and Toxicology
#14
of 483 outputs
Outputs of similar age
#10,445
of 239,572 outputs
Outputs of similar age from BMC Pharmacology and Toxicology
#3
of 15 outputs
Altmetric has tracked 25,372,398 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 483 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,572 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.