| Title |
Comprehensive analysis of loops at protein-protein interfaces for macrocycle design
|
|---|---|
| Published in |
Nature Chemical Biology, July 2014
|
| DOI | 10.1038/nchembio.1580 |
| Pubmed ID | |
| Authors |
Jason Gavenonis, Bradley A Sheneman, Timothy R Siegert, Matthew R Eshelman, Joshua A Kritzer |
| Abstract |
Inhibiting protein-protein interactions (PPIs) with synthetic molecules remains a frontier of chemical biology. Many PPIs have been successfully targeted by mimicking α-helices at interfaces, but most PPIs are mediated by nonhelical, nonstrand peptide loops. We sought to comprehensively identify and analyze these loop-mediated PPIs by writing and implementing LoopFinder, a customizable program that can identify loop-mediated PPIs within all of the protein-protein complexes in the Protein Data Bank. Comprehensive analysis of the entire set of 25,005 interface loops revealed common structural motifs and unique features that distinguish loop-mediated PPIs from other PPIs. 'Hot loops', named in analogy to protein hot spots, were identified as loops with favorable properties for mimicry using synthetic molecules. The hot loops and their binding partners represent new and promising PPIs for the development of macrocycle and constrained peptide inhibitors. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| Switzerland | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 292 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 4% |
| United Kingdom | 5 | 2% |
| Switzerland | 1 | <1% |
| Brazil | 1 | <1% |
| Germany | 1 | <1% |
| Czechia | 1 | <1% |
| Spain | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 270 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 92 | 32% |
| Researcher | 70 | 24% |
| Student > Bachelor | 29 | 10% |
| Student > Master | 20 | 7% |
| Other | 15 | 5% |
| Other | 40 | 14% |
| Unknown | 26 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 125 | 43% |
| Biochemistry, Genetics and Molecular Biology | 61 | 21% |
| Agricultural and Biological Sciences | 47 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 2% |
| Engineering | 5 | 2% |
| Other | 18 | 6% |
| Unknown | 31 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2024.
All research outputs
#6,934,435
of 25,387,668 outputs
Outputs from Nature Chemical Biology
#2,306
of 3,389 outputs
Outputs of similar age
#60,967
of 239,933 outputs
Outputs of similar age from Nature Chemical Biology
#40
of 46 outputs
Altmetric has tracked 25,387,668 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 3,389 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.8. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,933 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.