| Title |
Cancer chemoprevention: scientific promise, clinical uncertainty
|
|---|---|
| Published in |
Nature Reviews Clinical Oncology, October 2005
|
| DOI | 10.1038/ncponc0319 |
| Pubmed ID | |
| Authors |
Michael B Sporn, Karen T Liby |
| Abstract |
We review fundamental processes, such as mutation, oxidative stress, and inflammation that are critical for carcinogenesis and provide specific molecular targets for new chemopreventive agents. New information from molecular biology studies has identified such targets, including regulatory molecules such as Nrf2 (nuclear factor erythroid 2-related factor 2), epidermal growth factor receptor kinases, phosphatidylinositol 3-kinase, components of the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway, nuclear factor-kappaB, and cyclin D. The development of new drugs for the control of these targets that are both safe and effective will be important for the future of cancer chemoprevention. |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 4% |
| France | 1 | 1% |
| Spain | 1 | 1% |
| Taiwan | 1 | 1% |
| Japan | 1 | 1% |
| Poland | 1 | 1% |
| Unknown | 74 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 18% |
| Student > Master | 11 | 13% |
| Researcher | 10 | 12% |
| Student > Bachelor | 9 | 11% |
| Student > Doctoral Student | 8 | 10% |
| Other | 13 | 16% |
| Unknown | 16 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 27% |
| Biochemistry, Genetics and Molecular Biology | 14 | 17% |
| Medicine and Dentistry | 10 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 7% |
| Chemistry | 6 | 7% |
| Other | 6 | 7% |
| Unknown | 18 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2014.
All research outputs
#4,836,328
of 25,374,917 outputs
Outputs from Nature Reviews Clinical Oncology
#1,004
of 2,340 outputs
Outputs of similar age
#11,700
of 70,235 outputs
Outputs of similar age from Nature Reviews Clinical Oncology
#3
of 9 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,340 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.8. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,235 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.