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The role of FKBP5 genotype in moderating long-term effectiveness of exposure-based psychotherapy for posttraumatic stress disorder

Overview of attention for article published in Translational Psychiatry, June 2014
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148 Mendeley
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Title
The role of FKBP5 genotype in moderating long-term effectiveness of exposure-based psychotherapy for posttraumatic stress disorder
Published in
Translational Psychiatry, June 2014
DOI 10.1038/tp.2014.49
Pubmed ID
Authors

S Wilker, A Pfeiffer, S Kolassa, T Elbert, B Lingenfelder, E Ovuga, A Papassotiropoulos, D de Quervain, I-T Kolassa

Abstract

Exposure-based therapies are considered the state-of-the-art treatment for Posttraumatic Stress Disorder (PTSD). Yet, a substantial number of PTSD patients do not recover after therapy. In the light of the well-known gene × environment interactions on the risk for PTSD, research on individual genetic factors that influence treatment success is warranted. The gene encoding FK506-binding protein 51 (FKBP5), a co-chaperone of the glucocorticoid receptor (GR), has been associated with stress reactivity and PTSD risk. As FKBP5 single-nucleotide polymorphism rs1360780 has a putative functional role in the regulation of FKBP5 expression and GR sensitivity, we hypothesized that this polymorphism influences PTSD treatment success. We investigated the effects of FKBP5 rs1360780 genotype on Narrative Exposure Therapy (NET) outcome, an exposure-based short-term therapy, in a sample of 43 survivors of the rebel war in Northern Uganda. PTSD symptom severity was assessed before and 4 and 10 months after treatment completion. At the 4-month follow-up, there were no genotype-dependent differences in therapy outcome. However, the FKBP5 genotype significantly moderated the long-term effectiveness of exposure-based psychotherapy. At the 10-month follow-up, carriers of the rs1360780 risk (T) allele were at increased risk of symptom relapse, whereas non-carriers showed continuous symptom reduction. This effect was reflected in a weaker treatment effect size (Cohen's D=1.23) in risk allele carriers compared with non-carriers (Cohen's D=3.72). Genetic factors involved in stress response regulation seem to not only influence PTSD risk but also responsiveness to psychotherapy and could hence represent valuable targets for accompanying medication.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Netherlands 1 <1%
Australia 1 <1%
Unknown 145 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 18%
Student > Master 20 14%
Student > Bachelor 17 11%
Researcher 11 7%
Student > Doctoral Student 10 7%
Other 27 18%
Unknown 36 24%
Readers by discipline Count As %
Psychology 49 33%
Medicine and Dentistry 22 15%
Neuroscience 16 11%
Biochemistry, Genetics and Molecular Biology 6 4%
Agricultural and Biological Sciences 5 3%
Other 9 6%
Unknown 41 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2015.
All research outputs
#13,916,367
of 22,757,541 outputs
Outputs from Translational Psychiatry
#2,244
of 3,217 outputs
Outputs of similar age
#116,948
of 228,106 outputs
Outputs of similar age from Translational Psychiatry
#19
of 32 outputs
Altmetric has tracked 22,757,541 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,217 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.6. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,106 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.