| Title |
A single genus in the gut microbiome reflects host preference and specificity
|
|---|---|
| Published in |
The ISME Journal, June 2014
|
| DOI | 10.1038/ismej.2014.97 |
| Pubmed ID | |
| Authors |
A Murat Eren, Mitchell L Sogin, Hilary G Morrison, Joseph H Vineis, Jenny C Fisher, Ryan J Newton, Sandra L McLellan |
| Abstract |
Delineating differences in gut microbiomes of human and animal hosts contributes towards understanding human health and enables new strategies for detecting reservoirs of waterborne human pathogens. We focused upon Blautia, a single microbial genus that is important for nutrient assimilation as preliminary work suggested host-related patterns within members of this genus. In our dataset of 57 M sequence reads of the V6 region of the 16S ribosomal RNA gene in samples collected from seven host species, we identified 200 high-resolution taxonomic units within Blautia using oligotyping. Our analysis revealed 13 host-specific oligotypes that occurred exclusively in fecal samples of humans (three oligotypes), swine (six oligotypes), cows (one oligotype), deer (one oligotype), or chickens (two oligotypes). We identified an additional 171 oligotypes that exhibited differential abundance patterns among all the host species. Blautia oligotypes in the human population obtained from sewage and fecal samples displayed remarkable continuity. Oligotypes from only 10 Brazilian human fecal samples collected from individuals in a rural village encompassed 97% of all Blautia oligotypes found in a Brazilian sewage sample from a city of three million people. Further, 75% of the oligotypes in Brazilian human fecal samples matched those in US sewage samples, implying that a universal set of Blautia strains may be shared among culturally and geographically distinct human populations. Such strains can serve as universal markers to assess human fecal contamination in environmental samples. Our results indicate that host-specificity and host-preference patterns of organisms within this genus are driven by host physiology more than dietary habits. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 30% |
| United Kingdom | 2 | 9% |
| France | 2 | 9% |
| Cameroon | 1 | 4% |
| Netherlands | 1 | 4% |
| Switzerland | 1 | 4% |
| Turkey | 1 | 4% |
| Germany | 1 | 4% |
| Unknown | 7 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 52% |
| Scientists | 10 | 43% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 368 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 16 | 4% |
| Germany | 3 | <1% |
| France | 2 | <1% |
| Belgium | 2 | <1% |
| Spain | 2 | <1% |
| Netherlands | 1 | <1% |
| Sweden | 1 | <1% |
| Slovenia | 1 | <1% |
| Mexico | 1 | <1% |
| Other | 5 | 1% |
| Unknown | 334 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 93 | 25% |
| Researcher | 86 | 23% |
| Student > Master | 41 | 11% |
| Student > Bachelor | 29 | 8% |
| Student > Doctoral Student | 24 | 7% |
| Other | 65 | 18% |
| Unknown | 30 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 171 | 46% |
| Biochemistry, Genetics and Molecular Biology | 39 | 11% |
| Immunology and Microbiology | 29 | 8% |
| Environmental Science | 23 | 6% |
| Medicine and Dentistry | 16 | 4% |
| Other | 46 | 13% |
| Unknown | 44 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2023.
All research outputs
#2,287,258
of 25,457,858 outputs
Outputs from The ISME Journal
#1,237
of 3,273 outputs
Outputs of similar age
#22,348
of 242,813 outputs
Outputs of similar age from The ISME Journal
#9
of 63 outputs
Altmetric has tracked 25,457,858 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,273 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.9. This one has gotten more attention than average, scoring higher than 62% of its peers.
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