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Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues

Overview of attention for article published in Nature Immunology, August 2017
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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Title
Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues
Published in
Nature Immunology, August 2017
DOI 10.1038/ni.3799
Pubmed ID
Authors

Michael Delacher, Charles D Imbusch, Dieter Weichenhan, Achim Breiling, Agnes Hotz-Wagenblatt, Ulrike Träger, Ann-Cathrin Hofer, Danny Kägebein, Qi Wang, Felix Frauhammer, Jan-Philipp Mallm, Katharina Bauer, Carl Herrmann, Philipp A Lang, Benedikt Brors, Christoph Plass, Markus Feuerer

Abstract

Regulatory T cells (Treg cells) perform two distinct functions: they maintain self-tolerance, and they support organ homeostasis by differentiating into specialized tissue Treg cells. We found that epigenetic modifications defined the molecular characteristics of tissue Treg cells. Tagmentation-based whole-genome bisulfite sequencing revealed more than 11,000 regions that were methylated differentially in pairwise comparisons of tissue Treg cell populations and lymphoid T cells. Similarities in the epigenetic landscape led to the identification of a common tissue Treg cell population that was present in many organs and was characterized by gain and loss of DNA methylation that included many gene sites associated with the TH2 subset of helper T cells, such as the gene encoding cytokine IL-33 receptor ST2, as well as the production of tissue-regenerative factors. Furthermore, the ST2-expressing population was dependent on the transcriptional regulator BATF and could be expanded by IL-33. Thus, tissue Treg cells integrate multiple waves of epigenetic reprogramming that define their tissue-restricted specialization.

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X Demographics

The data shown below were collected from the profiles of 40 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 262 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 262 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 66 25%
Researcher 54 21%
Student > Master 27 10%
Student > Doctoral Student 15 6%
Student > Bachelor 12 5%
Other 32 12%
Unknown 56 21%
Readers by discipline Count As %
Immunology and Microbiology 76 29%
Biochemistry, Genetics and Molecular Biology 48 18%
Agricultural and Biological Sciences 38 15%
Medicine and Dentistry 20 8%
Engineering 4 2%
Other 15 6%
Unknown 61 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2021.
All research outputs
#1,160,510
of 24,286,850 outputs
Outputs from Nature Immunology
#755
of 4,014 outputs
Outputs of similar age
#24,102
of 321,148 outputs
Outputs of similar age from Nature Immunology
#13
of 48 outputs
Altmetric has tracked 24,286,850 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,014 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.1. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,148 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.