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Reprogramming of the chick retinal pigmented epithelium after retinal injury

Overview of attention for article published in BMC Biology, April 2014
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Title
Reprogramming of the chick retinal pigmented epithelium after retinal injury
Published in
BMC Biology, April 2014
DOI 10.1186/1741-7007-12-28
Pubmed ID
Authors

Agustin Luz-Madrigal, Erika Grajales-Esquivel, Alexander McCorkle, Ashley M DiLorenzo, Karla Barbosa-Sabanero, Panagiotis A Tsonis, Katia Del Rio-Tsonis

Abstract

One of the promises in regenerative medicine is to regenerate or replace damaged tissues. The embryonic chick can regenerate its retina by transdifferentiation of the retinal pigmented epithelium (RPE) and by activation of stem/progenitor cells present in the ciliary margin. These two ways of regeneration occur concomitantly when an external source of fibroblast growth factor 2 (FGF2) is present after injury (retinectomy). During the process of transdifferentiation, the RPE loses its pigmentation and is reprogrammed to become neuroepithelium, which differentiates to reconstitute the different cell types of the neural retina. Somatic mammalian cells can be reprogrammed to become induced pluripotent stem cells by ectopic expression of pluripotency-inducing factors such as Oct4, Sox2, Klf4, c-Myc and in some cases Nanog and Lin-28. However, there is limited information concerning the expression of these factors during natural regenerative processes. Organisms that are able to regenerate their organs could share similar mechanisms and factors with the reprogramming process of somatic cells. Herein, we investigate the expression of pluripotency-inducing factors in the RPE after retinectomy (injury) and during transdifferentiation in the presence of FGF2.

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Geographical breakdown

Country Count As %
Unknown 85 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 22%
Student > Ph. D. Student 17 20%
Student > Bachelor 14 16%
Student > Master 10 12%
Student > Doctoral Student 8 9%
Other 14 16%
Unknown 3 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 39 46%
Biochemistry, Genetics and Molecular Biology 18 21%
Neuroscience 8 9%
Medicine and Dentistry 5 6%
Veterinary Science and Veterinary Medicine 1 1%
Other 8 9%
Unknown 6 7%