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Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder

Overview of attention for article published in Molecular Psychiatry, May 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

blogs
1 blog
policy
1 policy source
twitter
8 X users
facebook
2 Facebook pages
wikipedia
4 Wikipedia pages

Citations

dimensions_citation
226 Dimensions

Readers on

mendeley
293 Mendeley
citeulike
1 CiteULike
connotea
1 Connotea
Title
Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder
Published in
Molecular Psychiatry, May 2009
DOI 10.1038/mp.2009.50
Pubmed ID
Authors

M H Bloch, J McGuire, A Landeros-Weisenberger, J F Leckman, C Pittenger

Abstract

We sought to determine differences in efficacy and tolerability between different doses of selective serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder (OCD) using meta-analysis. We identified 9 studies involving 2268 subjects that were randomized, double-blind placebo-controlled clinical trials that compared multiple, fixed-doses of selective serotonin reuptake inhibitors (SSRIs) to each other and to placebo in the treatment of adults with OCD. Change in Y-BOCS score, proportion of treatment responders, and dropouts (all-cause and due to side-effects) were determined for each included study. Weighted mean difference was used to examine mean change in Y-BOCS score. Pooled absolute risk difference was used to examine dichotomous outcomes. Meta-analysis was performed using a fixed effects model in RevMan 4.2.8. We found that compared with either low or medium doses, higher doses of SSRIs were associated with improved treatment efficacy, using either Y-BOCS score or proportion of treatment responders as an outcome. Dose of SSRIs was not associated with the number of all-cause dropouts. Higher doses of SSRIs were associated with significantly higher proportion of dropouts due to side-effects. These results suggests that higher doses of SSRIs are associated with greater efficacy in the treatment of OCD. This SSRI efficacy pattern stands in contrast to other psychiatric disorders like Major Depressive Disorder. This greater treatment efficacy is somewhat counterbalanced by the greater side-effect burden with higher doses of SSRIs. At present, there are insufficient data to generalize these findings to children or adolescents with OCD.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 293 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
France 1 <1%
Brazil 1 <1%
Sweden 1 <1%
Canada 1 <1%
Greece 1 <1%
Unknown 287 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 44 15%
Student > Ph. D. Student 37 13%
Student > Master 37 13%
Researcher 32 11%
Other 23 8%
Other 60 20%
Unknown 60 20%
Readers by discipline Count As %
Medicine and Dentistry 100 34%
Psychology 55 19%
Neuroscience 22 8%
Agricultural and Biological Sciences 16 5%
Pharmacology, Toxicology and Pharmaceutical Science 5 2%
Other 20 7%
Unknown 75 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2022.
All research outputs
#1,472,943
of 23,767,404 outputs
Outputs from Molecular Psychiatry
#1,128
of 4,264 outputs
Outputs of similar age
#4,584
of 112,697 outputs
Outputs of similar age from Molecular Psychiatry
#6
of 19 outputs
Altmetric has tracked 23,767,404 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,264 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.6. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 112,697 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.