| Title |
Impairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol
|
|---|---|
| Published in |
Scientific Reports, July 2017
|
| DOI | 10.1038/s41598-017-04764-9 |
| Pubmed ID | |
| Authors |
Genane Loheswaran, Mera S. Barr, Reza Zomorrodi, Tarek K. Rajji, Daniel M. Blumberger, Bernard Le Foll, Zafiris J. Daskalakis |
| Abstract |
Previous studies have demonstrated that alcohol consumption impairs neuroplasticity in the motor cortex. However, it is unknown whether alcohol produces a similar impairment of neuroplasticity in the dorsolateral prefrontal cortex (DLPFC), a brain region that plays an important role in cognitive functioning. The aim of the current study was to evaluate the effect of alcohol intoxication on neuroplasticity in the DLPFC. Paired associative stimulation (PAS) combined with electroencephalography (EEG) was used for the induction and measurement of associative LTP-like neuroplasticity in the DLPFC. Fifteen healthy subjects were administered PAS to the DLPFC following consumption of an alcohol (1.5 g/l of body water) or placebo beverage in a within-subject cross-over design. PAS induced neuroplasticity was indexed up to 60 minutes following PAS. Additionally, the effect of alcohol on PAS-induced potentiation of theta-gamma coupling (an index associated with learning and memory) was examined prior to and following PAS. Alcohol consumption resulted in a significant impairment of mean (t = 2.456, df = 13, p = 0.029) and maximum potentiation (t = -2.945, df = 13, p = 0.011) compared to the placebo beverage in the DLPFC and globally. Alcohol also suppressed the potentiation of theta-gamma coupling by PAS. Findings from the present study provide a potential neurophysiological mechanism for impairment of cognitive functioning by alcohol. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 20% |
| Egypt | 1 | 20% |
| United States | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 85 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 19% |
| Student > Ph. D. Student | 11 | 13% |
| Student > Master | 10 | 12% |
| Researcher | 7 | 8% |
| Student > Doctoral Student | 5 | 6% |
| Other | 11 | 13% |
| Unknown | 25 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 14% |
| Psychology | 12 | 14% |
| Neuroscience | 11 | 13% |
| Nursing and Health Professions | 7 | 8% |
| Agricultural and Biological Sciences | 3 | 4% |
| Other | 6 | 7% |
| Unknown | 34 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2020.
All research outputs
#13,047,019
of 22,988,380 outputs
Outputs from Scientific Reports
#56,680
of 124,114 outputs
Outputs of similar age
#148,728
of 312,390 outputs
Outputs of similar age from Scientific Reports
#2,341
of 5,407 outputs
Altmetric has tracked 22,988,380 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 124,114 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has gotten more attention than average, scoring higher than 53% of its peers.
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We're also able to compare this research output to 5,407 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.