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Activation pathway of Src kinase reveals intermediate states as targets for drug design.

Overview of attention for article published in Nature Communications, March 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Citations

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164 Dimensions

Readers on

mendeley
190 Mendeley
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1 CiteULike
Title
Activation pathway of Src kinase reveals intermediate states as targets for drug design.
Published in
Nature Communications, March 2014
DOI 10.1038/ncomms4397
Pubmed ID
Authors

Diwakar Shukla, Yilin Meng, Benoît Roux, Vijay S. Pande, Shukla D, Meng Y, Roux B, Pande VS

Abstract

Unregulated activation of Src kinases leads to aberrant signalling, uncontrolled growth and differentiation of cancerous cells. Reaching a complete mechanistic understanding of large-scale conformational transformations underlying the activation of kinases could greatly help in the development of therapeutic drugs for the treatment of these pathologies. In principle, the nature of conformational transition could be modelled in silico via atomistic molecular dynamics simulations, although this is very challenging because of the long activation timescales. Here we employ a computational paradigm that couples transition pathway techniques and Markov state model-based massively distributed simulations for mapping the conformational landscape of c-src tyrosine kinase. The computations provide the thermodynamics and kinetics of kinase activation for the first time, and help identify key structural intermediates. Furthermore, the presence of a novel allosteric site in an intermediate state of c-src that could be potentially used for drug design is predicted.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 190 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 3%
United Kingdom 4 2%
Germany 2 1%
Japan 2 1%
Italy 2 1%
India 1 <1%
France 1 <1%
China 1 <1%
Switzerland 1 <1%
Other 2 1%
Unknown 169 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 61 32%
Researcher 60 32%
Student > Bachelor 18 9%
Student > Master 15 8%
Other 9 5%
Other 27 14%
Readers by discipline Count As %
Chemistry 57 30%
Agricultural and Biological Sciences 46 24%
Biochemistry, Genetics and Molecular Biology 33 17%
Physics and Astronomy 26 14%
Computer Science 9 5%
Other 19 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 50. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2014.
All research outputs
#248,415
of 11,344,729 outputs
Outputs from Nature Communications
#4,295
of 16,909 outputs
Outputs of similar age
#5,645
of 183,961 outputs
Outputs of similar age from Nature Communications
#109
of 466 outputs
Altmetric has tracked 11,344,729 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 16,909 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 46.6. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 183,961 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 466 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.