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Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory

Overview of attention for article published in Nature, May 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

news
11 news outlets
blogs
4 blogs
twitter
198 tweeters
patent
1 patent
peer_reviews
1 peer review site
facebook
6 Facebook pages
wikipedia
2 Wikipedia pages
reddit
1 Redditor

Citations

dimensions_citation
172 Dimensions

Readers on

mendeley
396 Mendeley
citeulike
1 CiteULike
Title
Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory
Published in
Nature, May 2017
DOI 10.1038/nature22405
Pubmed ID
Authors

Philipp Mews, Greg Donahue, Adam M. Drake, Vincent Luczak, Ted Abel, Shelley L. Berger

Abstract

Metabolic production of acetyl coenzyme A (acetyl-CoA) is linked to histone acetylation and gene regulation, but the precise mechanisms of this process are largely unknown. Here we show that the metabolic enzyme acetyl-CoA synthetase 2 (ACSS2) directly regulates histone acetylation in neurons and spatial memory in mammals. In a neuronal cell culture model, ACSS2 increases in the nuclei of differentiating neurons and localizes to upregulated neuronal genes near sites of elevated histone acetylation. A decrease in ACSS2 lowers nuclear acetyl-CoA levels, histone acetylation, and responsive expression of the cohort of neuronal genes. In adult mice, attenuation of hippocampal ACSS2 expression impairs long-term spatial memory, a cognitive process that relies on histone acetylation. A decrease in ACSS2 in the hippocampus also leads to defective upregulation of memory-related neuronal genes that are pre-bound by ACSS2. These results reveal a connection between cellular metabolism, gene regulation, and neural plasticity and establish a link between acetyl-CoA generation 'on-site' at chromatin for histone acetylation and the transcription of key neuronal genes.

Twitter Demographics

The data shown below were collected from the profiles of 198 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 396 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
Unknown 393 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 114 29%
Researcher 64 16%
Student > Bachelor 47 12%
Student > Master 33 8%
Student > Doctoral Student 20 5%
Other 67 17%
Unknown 51 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 119 30%
Agricultural and Biological Sciences 86 22%
Neuroscience 65 16%
Medicine and Dentistry 29 7%
Pharmacology, Toxicology and Pharmaceutical Science 8 2%
Other 30 8%
Unknown 59 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 224. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2020.
All research outputs
#93,652
of 17,833,983 outputs
Outputs from Nature
#7,971
of 80,473 outputs
Outputs of similar age
#2,877
of 279,281 outputs
Outputs of similar age from Nature
#202
of 761 outputs
Altmetric has tracked 17,833,983 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 80,473 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 90.8. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,281 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 761 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.