| Title |
Transdifferentiation of parathyroid cells into cervical thymi promotes atypical T-cell development
|
|---|---|
| Published in |
Nature Communications, December 2013
|
| DOI | 10.1038/ncomms3959 |
| Pubmed ID | |
| Authors |
Jie Li, Zhijie Liu, Shiyun Xiao, Nancy R. Manley |
| Abstract |
The thoracic thymus is the primary vertebrate organ for T-cell generation. Accessory cervical thymi have also been identified in humans and mice, and shown in mice to be independent functional organs that support T-cell development. However, their origin and functional significance remain unclear. Here we show that cervical thymi in mice have following two origins: delayed differentiation of endodermal precursors and transdifferentiation of parathyroid-fated cells. Compared with thoracic thymus, parathyroid-origin cervical thymi (pCT) express low levels of the thymic epithelial cell-specific transcription factor FOXN1. Consequently, pCT form a distinct microenvironment that supports an atypical thymocyte development pathway, generating T cells with unconventional phenotypic characteristics. Our data demonstrate a transdifferentiation origin for a subset of cervical thymi, with specific functional consequences for T-cell development. |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 6% |
| Unknown | 15 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 25% |
| Student > Master | 2 | 13% |
| Lecturer > Senior Lecturer | 1 | 6% |
| Professor | 1 | 6% |
| Student > Bachelor | 1 | 6% |
| Other | 2 | 13% |
| Unknown | 5 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 31% |
| Immunology and Microbiology | 4 | 25% |
| Biochemistry, Genetics and Molecular Biology | 2 | 13% |
| Unknown | 5 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2014.
All research outputs
#938,538
of 22,741,406 outputs
Outputs from Nature Communications
#15,034
of 46,810 outputs
Outputs of similar age
#10,268
of 286,058 outputs
Outputs of similar age from Nature Communications
#111
of 407 outputs
Altmetric has tracked 22,741,406 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 46,810 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one has gotten more attention than average, scoring higher than 67% of its peers.
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We're also able to compare this research output to 407 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.