| Title |
Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid
|
|---|---|
| Published in |
Nature Communications, May 2017
|
| DOI | 10.1038/ncomms15126 |
| Pubmed ID | |
| Authors |
Stephan Düwel, Christian Hundshammer, Malte Gersch, Benedikt Feuerecker, Katja Steiger, Achim Buck, Axel Walch, Axel Haase, Steffen J. Glaser, Markus Schwaiger, Franz Schilling |
| Abstract |
Natural pH regulatory mechanisms can be overruled during several pathologies such as cancer, inflammation and ischaemia, leading to local pH changes in the human body. Here we demonstrate that (13)C-labelled zymonic acid (ZA) can be used as hyperpolarized magnetic resonance pH imaging sensor. ZA is synthesized from [1-(13)C]pyruvic acid and its (13)C resonance frequencies shift up to 3.0 p.p.m. per pH unit in the physiological pH range. The long lifetime of the hyperpolarized signal enhancement enables monitoring of pH, independent of concentration, temperature, ionic strength and protein concentration. We show in vivo pH maps within rat kidneys and subcutaneously inoculated tumours derived from a mammary adenocarcinoma cell line and characterize ZA as non-toxic compound predominantly present in the extracellular space. We suggest that ZA represents a reliable and non-invasive extracellular imaging sensor to localize and quantify pH, with the potential to improve understanding, diagnosis and therapy of diseases characterized by aberrant acid-base balance. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hungary | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 82 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 21% |
| Student > Ph. D. Student | 16 | 20% |
| Student > Bachelor | 7 | 9% |
| Other | 6 | 7% |
| Student > Master | 6 | 7% |
| Other | 10 | 12% |
| Unknown | 20 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 16 | 20% |
| Medicine and Dentistry | 8 | 10% |
| Biochemistry, Genetics and Molecular Biology | 6 | 7% |
| Physics and Astronomy | 5 | 6% |
| Engineering | 4 | 5% |
| Other | 10 | 12% |
| Unknown | 33 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 67. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2017.
All research outputs
#542,076
of 22,971,207 outputs
Outputs from Nature Communications
#9,556
of 47,274 outputs
Outputs of similar age
#12,515
of 310,860 outputs
Outputs of similar age from Nature Communications
#284
of 1,026 outputs
Altmetric has tracked 22,971,207 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 47,274 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.9. This one has done well, scoring higher than 79% of its peers.
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We're also able to compare this research output to 1,026 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.