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Adaptation to dietary conditions by trehalose metabolism in Drosophila

Overview of attention for article published in Scientific Reports, May 2017
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95 Mendeley
Title
Adaptation to dietary conditions by trehalose metabolism in Drosophila
Published in
Scientific Reports, May 2017
DOI 10.1038/s41598-017-01754-9
Pubmed ID
Authors

Tetsuo Yasugi, Takayuki Yamada, Takashi Nishimura

Abstract

Trehalose is a non-reducing disaccharide that serves as the main sugar component of haemolymph in insects. Trehalose hydrolysis enzyme, called trehalase, is highly conserved from bacteria to humans. However, our understanding of the physiological role of trehalase remains incomplete. Here, we analyze the phenotypes of several Trehalase (Treh) loss-of-function alleles in a comparative manner in Drosophila. The previously reported mutant phenotype of Treh affecting neuroepithelial stem cell maintenance and differentiation in the optic lobe is caused by second-site alleles in addition to Treh. We further report that the survival rate of Treh null mutants is significantly influenced by dietary conditions. Treh mutant larvae are lethal not only on a low-sugar diet but also under low-protein diet conditions. A reduction in adaptation ability under poor food conditions in Treh mutants is mainly caused by the overaccumulation of trehalose rather than the loss of Treh, because the additional loss of Tps1 mitigates the lethal effect of Treh mutants. These results demonstrate that proper trehalose metabolism plays a critical role in adaptation under various environmental conditions.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 95 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 24%
Researcher 16 17%
Student > Master 11 12%
Student > Doctoral Student 7 7%
Student > Bachelor 6 6%
Other 11 12%
Unknown 21 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 37 39%
Agricultural and Biological Sciences 28 29%
Neuroscience 2 2%
Unspecified 1 1%
Nursing and Health Professions 1 1%
Other 6 6%
Unknown 20 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2017.
All research outputs
#14,384,088
of 24,171,551 outputs
Outputs from Scientific Reports
#65,711
of 131,471 outputs
Outputs of similar age
#162,994
of 314,553 outputs
Outputs of similar age from Scientific Reports
#2,018
of 4,070 outputs
Altmetric has tracked 24,171,551 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 131,471 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.6. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,553 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,070 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.