| Title |
Epigenetic changes in blood leukocytes following an omega-3 fatty acid supplementation
|
|---|---|
| Published in |
Clinical Epigenetics, April 2017
|
| DOI | 10.1186/s13148-017-0345-3 |
| Pubmed ID | |
| Authors |
Bénédicte L. Tremblay, Frédéric Guénard, Iwona Rudkowska, Simone Lemieux, Patrick Couture, Marie-Claude Vohl |
| Abstract |
Omega-3 polyunsaturated fatty acids (n-3 FAs) have several beneficial effects on cardiovascular (CV) disease risk factors. These effects on CV risk profile may be mediated by several factors, including epigenetic modifications. Our objective is to investigate, using genome-wide DNA methylation analyses, methylation changes following an n-3 FA supplementation in overweight and obese subjects and to identify specific biological pathways potentially altered by the supplementation. Blood leukocytes genome-wide DNA methylation profiles of 36 overweight and obese subjects before and after a 6-week supplementation with 3 g of n-3 FAs were compared using GenomeStudio software. After supplementation, 308 CpG sites, assigned to 231 genes, were differentially methylated (FDR-corrected Diffscore ≥│13│~ P ≤ 0.05). Using Ingenuity Pathway Analysis system, a total of 55 pathways were significantly overrepresented following supplementation. Among these pathways, 16 were related to inflammatory and immune response, lipid metabolism, type 2 diabetes, and cardiovascular signaling. Changes in methylation levels of CpG sites within AKT3, ATF1, HDAC4, and IGFBP5 were correlated with changes in plasma triglyceride and glucose levels as well as with changes in the ratio of total cholesterol/HDL-cholesterol following the supplementation. These data provide key differences in blood leukocytes DNA methylation profiles of subjects following an n-3 FA supplementation, which brings new, potential insights on metabolic pathways underlying the effects of n-3 FAs on CV health. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 33% |
| Spain | 1 | 11% |
| France | 1 | 11% |
| Canada | 1 | 11% |
| Unknown | 3 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 78% |
| Practitioners (doctors, other healthcare professionals) | 2 | 22% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 94 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 16% |
| Student > Ph. D. Student | 14 | 15% |
| Student > Bachelor | 12 | 13% |
| Researcher | 10 | 11% |
| Professor | 4 | 4% |
| Other | 17 | 18% |
| Unknown | 22 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 21% |
| Biochemistry, Genetics and Molecular Biology | 14 | 15% |
| Nursing and Health Professions | 9 | 10% |
| Agricultural and Biological Sciences | 9 | 10% |
| Computer Science | 2 | 2% |
| Other | 13 | 14% |
| Unknown | 27 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2023.
All research outputs
#2,302,544
of 25,359,594 outputs
Outputs from Clinical Epigenetics
#143
of 1,434 outputs
Outputs of similar age
#41,469
of 316,195 outputs
Outputs of similar age from Clinical Epigenetics
#4
of 34 outputs
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