| Title |
Young genes are highly disordered as predicted by the preadaptation hypothesis of de novo gene birth
|
|---|---|
| Published in |
Nature Ecology & Evolution, April 2017
|
| DOI | 10.1038/s41559-017-0146 |
| Pubmed ID | |
| Authors |
Benjamin A. Wilson, Scott G. Foy, Rafik Neme, Joanna Masel |
| Abstract |
The phenomenon of de novo gene birth from junk DNA is surprising, because random polypeptides are expected to be toxic. There are two conflicting views about how de novo gene birth is nevertheless possible: the continuum hypothesis invokes a gradual gene birth process, while the preadaptation hypothesis predicts that young genes will show extreme levels of gene-like traits. We show that intrinsic structural disorder conforms to the predictions of the preadaptation hypothesis and falsifies the continuum hypothesis, with all genes having higher levels than translated junk DNA, but young genes having the highest level of all. Results are robust to homology detection bias, to the non-independence of multiple members of the same gene family, and to the false positive annotation of protein-coding genes. |
X Demographics
The data shown below were collected from the profiles of 56 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 10 | 18% |
| United States | 9 | 16% |
| Spain | 3 | 5% |
| France | 2 | 4% |
| Brazil | 2 | 4% |
| Ireland | 2 | 4% |
| Switzerland | 2 | 4% |
| Germany | 2 | 4% |
| Mexico | 1 | 2% |
| Other | 8 | 14% |
| Unknown | 15 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 27 | 48% |
| Scientists | 27 | 48% |
| Practitioners (doctors, other healthcare professionals) | 2 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 167 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Spain | 2 | 1% |
| Ireland | 1 | <1% |
| Norway | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 160 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 39 | 23% |
| Researcher | 30 | 18% |
| Student > Master | 24 | 14% |
| Student > Bachelor | 23 | 14% |
| Other | 6 | 4% |
| Other | 19 | 11% |
| Unknown | 26 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 64 | 38% |
| Biochemistry, Genetics and Molecular Biology | 53 | 32% |
| Computer Science | 4 | 2% |
| Environmental Science | 2 | 1% |
| Immunology and Microbiology | 2 | 1% |
| Other | 10 | 6% |
| Unknown | 32 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 77. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2022.
All research outputs
#545,177
of 25,161,628 outputs
Outputs from Nature Ecology & Evolution
#905
of 2,090 outputs
Outputs of similar age
#11,241
of 315,613 outputs
Outputs of similar age from Nature Ecology & Evolution
#40
of 81 outputs
Altmetric has tracked 25,161,628 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,090 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 150.4. This one has gotten more attention than average, scoring higher than 56% of its peers.
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We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.