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Bacteriophages from ExPEC Reservoirs Kill Pandemic Multidrug-Resistant Strains of Clonal Group ST131 in Animal Models of Bacteremia

Overview of attention for article published in Scientific Reports, April 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
14 news outlets
blogs
1 blog
twitter
33 X users
patent
1 patent
facebook
2 Facebook pages
googleplus
1 Google+ user
reddit
1 Redditor

Citations

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39 Dimensions

Readers on

mendeley
126 Mendeley
Title
Bacteriophages from ExPEC Reservoirs Kill Pandemic Multidrug-Resistant Strains of Clonal Group ST131 in Animal Models of Bacteremia
Published in
Scientific Reports, April 2017
DOI 10.1038/srep46151
Pubmed ID
Authors

Sabrina I. Green, Jason T. Kaelber, Li Ma, Barbara W. Trautner, Robert F. Ramig, Anthony W. Maresso

Abstract

Multi-drug resistant (MDR) enteric bacteria are of increasing global concern. A clonal group, Escherichia coli sequence type (ST) 131, harbors both MDR and a deadly complement of virulence factors. Patients with an immunocompromised system are at high risk of infections with these E. coli and there is strong epidemiologic evidence that the human intestinal tract, as well as household pets, may be a reservoir. Here, we examine if phages are an effective treatment strategy against this clonal group in murine models of bacteremia that recapitulate clinical infections. Bacteriophages isolated from known E. coli reservoirs lyse a diverse array of MDR ST131 clinical isolates. Phage HP3 reduced E. coli levels and improved health scores for mice infected with two distinct ST131 strains. Efficacy was correlated to in vitro lysis ability by the infecting phage and the level of virulence of the E. coli strain. Importantly, it is also demonstrated that E. coli bacteremia initiated from translocation across the intestinal tract in an immunocompromised host is substantially reduced after phage treatment. This study demonstrates that phage, isolated from the environment and with little experimental manipulation, can be effective in combating even the most serious of infections by E. coli "superbugs".

X Demographics

X Demographics

The data shown below were collected from the profiles of 33 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Unknown 125 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 18%
Researcher 17 13%
Student > Bachelor 17 13%
Student > Master 13 10%
Student > Postgraduate 6 5%
Other 20 16%
Unknown 30 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 27 21%
Agricultural and Biological Sciences 25 20%
Immunology and Microbiology 16 13%
Medicine and Dentistry 10 8%
Veterinary Science and Veterinary Medicine 5 4%
Other 12 10%
Unknown 31 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 131. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2023.
All research outputs
#317,467
of 25,459,177 outputs
Outputs from Scientific Reports
#3,616
of 141,171 outputs
Outputs of similar age
#6,669
of 324,812 outputs
Outputs of similar age from Scientific Reports
#130
of 4,245 outputs
Altmetric has tracked 25,459,177 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 141,171 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,812 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 4,245 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.