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Phenotype of postural instability/gait difficulty in Parkinson disease: relevance to cognitive impairment and mechanism relating pathological proteins and neurotransmitters

Overview of attention for article published in Scientific Reports, March 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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1 news outlet
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1 X user

Citations

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85 Mendeley
Title
Phenotype of postural instability/gait difficulty in Parkinson disease: relevance to cognitive impairment and mechanism relating pathological proteins and neurotransmitters
Published in
Scientific Reports, March 2017
DOI 10.1038/srep44872
Pubmed ID
Authors

Li-Jun Zuo, Ying-Shan Piao, Li-Xia Li, Shu-Yang Yu, Peng Guo, Yang Hu, Teng-Hong Lian, Rui-Dan Wang, Qiu-Jin Yu, Zhao Jin, Ya-Jie Wang, Xiao-Min Wang, Piu Chan, Sheng-Di Chen, Yong-Jun Wang, Wei Zhang

Abstract

Parkinson disease (PD) is identified as tremor-dominant (TD) and postural instability and gait difficulty (PIGD) phenotypes. The relationships between motor phenotypes and cognitive impairment and the underlying mechanisms relating pathological proteins and neurotransmitters in cerebrospinal fluid (CSF) are unknown. We evaluated the motor symptoms and cognitive function by scales, and detected the levels of pathological proteins and neurotransmitters in CSF. TD group and PIGD group had significantly higher levels of total tau, tau phosphorylated at the position of threonine 181(P-tau181t), threonine 231, serine 396, serine 199 and lower β amyloid (Aβ)1-42 level in CSF than those in control group; PIGD group had significantly higher P-tau181t level and lower Aβ1-42 level than those in TD group. In PD group, PIGD severity was negatively correlated with MoCA score and Aβ1-42 level in CSF, and positively correlated with Hoehn-Yahr stage and P-tau181t level in CSF. In PIGD group, PIGD severity was negatively correlated with homovanillic acid (HVA) level in CSF, and HVA level was positively correlated with Aβ1-42 level in CSF. PIGD was significantly correlated with cognitive impairment, which underlying mechanism might be involved in Aβ1-42 aggregation in brain and relevant neurochemical disturbance featured by the depletion of HVA in CSF.

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Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 85 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 14%
Researcher 12 14%
Student > Master 12 14%
Student > Bachelor 7 8%
Student > Doctoral Student 5 6%
Other 8 9%
Unknown 29 34%
Readers by discipline Count As %
Neuroscience 16 19%
Medicine and Dentistry 11 13%
Agricultural and Biological Sciences 4 5%
Sports and Recreations 3 4%
Engineering 3 4%
Other 12 14%
Unknown 36 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2017.
All research outputs
#3,222,551
of 22,961,203 outputs
Outputs from Scientific Reports
#27,599
of 123,970 outputs
Outputs of similar age
#61,824
of 309,217 outputs
Outputs of similar age from Scientific Reports
#1,081
of 4,417 outputs
Altmetric has tracked 22,961,203 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 123,970 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 309,217 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 4,417 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.