| Title |
Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort
|
|---|---|
| Published in |
Genetics in Medicine, March 2017
|
| DOI | 10.1038/gim.2017.4 |
| Pubmed ID | |
| Authors |
Iris Lianne Maas, Petra Brüggemann, Teresa Requena, Jan Bulla, Niklas K. Edvall, Jacob v.B. Hjelmborg, Agnieszka J. Szczepek, Barbara Canlon, Birgit Mazurek, Jose A. Lopez-Escamez, Christopher R. Cederroth |
| Abstract |
Genetic contributions to tinnitus have been difficult to determine due to the heterogeneity of the condition and its broad etiology. Here, we evaluated the genetic and nongenetic influences on self-reported tinnitus from the Swedish Twin Registry (STR). Cross-sectional data from the STR was obtained. Casewise concordance rates (the risk of one twin being affected given that his/her twin partner has tinnitus) were compared for monozygotic (MZ) and dizygotic (DZ) twin pairs (N = 10,464 concordant and discordant twin pairs) and heritability coefficients (the proportion of the total variance attributable to genetic factors) were calculated using biometrical model fitting procedures. Stratification of tinnitus cases into subtypes according to laterality (unilateral versus bilateral) revealed that heritability of bilateral tinnitus was 0.56; however, it was 0.27 for unilateral tinnitus. Heritability was greater in men (0.68) than in women (0.41). However, when female pairs younger than 40 years of age were selected, heritability of 0.62 was achieved with negligible effects of shared environment. Unlike unilateral tinnitus, bilateral tinnitus is influenced by genetic factors and might constitute a genetic subtype. Overall, our study provides the initial evidence for a tinnitus phenotype with a genetic influence.Genet Med advance online publication 23 March 2017Genetics in Medicine (2017); doi:10.1038/gim.2017.4. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 2 | 13% |
| United States | 1 | 6% |
| Denmark | 1 | 6% |
| Spain | 1 | 6% |
| United Kingdom | 1 | 6% |
| Netherlands | 1 | 6% |
| Unknown | 9 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 75% |
| Scientists | 3 | 19% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Unknown | 70 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 14% |
| Student > Master | 10 | 14% |
| Researcher | 8 | 11% |
| Other | 5 | 7% |
| Student > Bachelor | 4 | 6% |
| Other | 13 | 18% |
| Unknown | 21 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 24% |
| Agricultural and Biological Sciences | 9 | 13% |
| Psychology | 6 | 8% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Neuroscience | 4 | 6% |
| Other | 8 | 11% |
| Unknown | 22 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 78. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2023.
All research outputs
#544,613
of 25,382,440 outputs
Outputs from Genetics in Medicine
#142
of 2,944 outputs
Outputs of similar age
#11,380
of 322,668 outputs
Outputs of similar age from Genetics in Medicine
#3
of 37 outputs
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So far Altmetric has tracked 2,944 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.0. This one has done particularly well, scoring higher than 95% of its peers.
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