Title |
p11 and its role in depression and therapeutic responses to antidepressants
|
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Published in |
Nature Reviews Neuroscience, September 2013
|
DOI | 10.1038/nrn3564 |
Pubmed ID | |
Authors |
Per Svenningsson, Yong Kim, Jennifer Warner-Schmidt, Yong-Seok Oh, Paul Greengard |
Abstract |
Studies of the multifunctional protein p11 (also known as S100A10) are shedding light on the molecular and cellular mechanisms underlying depression. Here, we review data implicating p11 in both the amplification of serotonergic signalling and the regulation of gene transcription. We summarize studies demonstrating that levels of p11 are regulated in depression and by antidepressant regimens and, conversely, that p11 regulates depression-like behaviours and/or responses to antidepressants. Current and future studies of p11 may provide a molecular and cellular framework for the development of novel antidepressant therapies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 31% |
Japan | 2 | 13% |
United Kingdom | 2 | 13% |
Canada | 1 | 6% |
Italy | 1 | 6% |
Unknown | 5 | 31% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 14 | 88% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Scientists | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 2% |
Italy | 1 | <1% |
Germany | 1 | <1% |
Canada | 1 | <1% |
Unknown | 187 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 40 | 21% |
Researcher | 35 | 18% |
Student > Master | 22 | 11% |
Student > Bachelor | 18 | 9% |
Student > Doctoral Student | 11 | 6% |
Other | 37 | 19% |
Unknown | 31 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 44 | 23% |
Neuroscience | 42 | 22% |
Medicine and Dentistry | 26 | 13% |
Biochemistry, Genetics and Molecular Biology | 23 | 12% |
Psychology | 7 | 4% |
Other | 14 | 7% |
Unknown | 38 | 20% |