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Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties

Overview of attention for article published in Scientific Reports, March 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
18 news outlets
blogs
1 blog
twitter
163 X users
facebook
3 Facebook pages
googleplus
1 Google+ user

Citations

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76 Dimensions

Readers on

mendeley
143 Mendeley
Title
Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties
Published in
Scientific Reports, March 2017
DOI 10.1038/srep43399
Pubmed ID
Authors

Shaocheng Ma, En Lin Goh, Andi Jin, Rajarshi Bhattacharya, Oliver R. Boughton, Bhavi Patel, Angelo Karunaratne, Nghia T. Vo, Robert Atwood, Justin P. Cobb, Ulrich Hansen, Richard L. Abel

Abstract

Osteoporosis is characterised by trabecular bone loss resulting from increased osteoclast activation and unbalanced coupling between resorption and formation, which induces a thinning of trabeculae and trabecular perforations. Bisphosphonates are the frontline therapy for osteoporosis, which act by reducing bone remodelling, and are thought to prevent perforations and maintain microstructure. However, bisphosphonates may oversuppress remodelling resulting in accumulation of microcracks. This paper aims to investigate the effect of bisphosphonate treatment on microstructure and mechanical strength. Assessment of microdamage within the trabecular bone core was performed using synchrotron X-ray micro-CT linked to image analysis software. Bone from bisphosphonate-treated fracture patients exhibited fewer perforations but more numerous and larger microcracks than both fracture and non-fracture controls. Furthermore, bisphosphonate-treated bone demonstrated reduced tensile strength and Young's Modulus. These findings suggest that bisphosphonate therapy is effective at reducing perforations but may also cause microcrack accumulation, leading to a loss of microstructural integrity and consequently, reduced mechanical strength.

X Demographics

X Demographics

The data shown below were collected from the profiles of 163 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 143 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 29 20%
Student > Master 20 14%
Researcher 17 12%
Student > Bachelor 17 12%
Student > Postgraduate 12 8%
Other 18 13%
Unknown 30 21%
Readers by discipline Count As %
Medicine and Dentistry 33 23%
Engineering 21 15%
Biochemistry, Genetics and Molecular Biology 11 8%
Agricultural and Biological Sciences 6 4%
Nursing and Health Professions 5 3%
Other 28 20%
Unknown 39 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 276. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 April 2022.
All research outputs
#130,798
of 25,576,801 outputs
Outputs from Scientific Reports
#1,623
of 141,824 outputs
Outputs of similar age
#2,991
of 325,038 outputs
Outputs of similar age from Scientific Reports
#57
of 4,586 outputs
Altmetric has tracked 25,576,801 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 141,824 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,038 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 4,586 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.