Title |
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects
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Published in |
BMC Medicine, February 2017
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DOI | 10.1186/s12916-017-0778-8 |
Pubmed ID | |
Authors |
Ilaria Di Donato, Silvia Bianchi, Nicola De Stefano, Martin Dichgans, Maria Teresa Dotti, Marco Duering, Eric Jouvent, Amos D. Korczyn, Saskia A. J. Lesnik-Oberstein, Alessandro Malandrini, Hugh S. Markus, Leonardo Pantoni, Silvana Penco, Alessandra Rufa, Osman Sinanović, Dragan Stojanov, Antonio Federico |
Abstract |
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common and best known monogenic small vessel disease. Here, we review the clinical, neuroimaging, neuropathological, genetic, and therapeutic aspects based on the most relevant articles published between 1994 and 2016 and on the personal experience of the authors, all directly involved in CADASIL research and care. We conclude with some suggestions that may help in the clinical practice and management of these patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 20% |
United States | 2 | 20% |
Germany | 1 | 10% |
Sweden | 1 | 10% |
Unknown | 4 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 60% |
Practitioners (doctors, other healthcare professionals) | 3 | 30% |
Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 228 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 34 | 15% |
Researcher | 30 | 13% |
Other | 23 | 10% |
Student > Ph. D. Student | 21 | 9% |
Student > Master | 20 | 9% |
Other | 43 | 19% |
Unknown | 57 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 71 | 31% |
Neuroscience | 33 | 14% |
Biochemistry, Genetics and Molecular Biology | 15 | 7% |
Psychology | 12 | 5% |
Agricultural and Biological Sciences | 7 | 3% |
Other | 20 | 9% |
Unknown | 70 | 31% |