| Title |
Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning
|
|---|---|
| Published in |
Nature Neuroscience, February 2017
|
| DOI | 10.1038/nn.4503 |
| Pubmed ID | |
| Authors |
Fergil Mills, Andrea K Globa, Shuai Liu, Catherine M Cowan, Mahsan Mobasser, Anthony G Phillips, Stephanie L Borgland, Shernaz X Bamji |
| Abstract |
Drugs of abuse alter synaptic connections in the reward circuitry of the brain, which leads to long-lasting behavioral changes that underlie addiction. Here we show that cadherin adhesion molecules play a critical role in mediating synaptic plasticity and behavioral changes driven by cocaine. We demonstrate that cadherin is essential for long-term potentiation in the ventral tegmental area and is recruited to the synaptic membranes of excitatory synapses onto dopaminergic neurons following cocaine-mediated behavioral conditioning. Furthermore, we show that stabilization of cadherin at the membrane of these synapses blocks cocaine-induced synaptic plasticity, leading to a reduction in conditioned place preference induced by cocaine. Our findings identify cadherins and associated molecules as targets of interest for understanding pathological plasticity associated with addiction. |
X Demographics
The data shown below were collected from the profiles of 58 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 17 | 29% |
| United States | 12 | 21% |
| United Kingdom | 2 | 3% |
| Belgium | 1 | 2% |
| Ireland | 1 | 2% |
| Japan | 1 | 2% |
| Switzerland | 1 | 2% |
| Italy | 1 | 2% |
| Korea, Republic of | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 18 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 37 | 64% |
| Scientists | 18 | 31% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
| Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Turkey | 1 | <1% |
| Austria | 1 | <1% |
| Unknown | 131 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 24% |
| Researcher | 24 | 18% |
| Student > Bachelor | 21 | 16% |
| Student > Master | 11 | 8% |
| Professor | 7 | 5% |
| Other | 12 | 9% |
| Unknown | 27 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 51 | 38% |
| Agricultural and Biological Sciences | 18 | 13% |
| Biochemistry, Genetics and Molecular Biology | 11 | 8% |
| Medicine and Dentistry | 11 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Other | 10 | 7% |
| Unknown | 30 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 590. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2018.
All research outputs
#37,799
of 24,891,087 outputs
Outputs from Nature Neuroscience
#56
of 5,533 outputs
Outputs of similar age
#859
of 437,241 outputs
Outputs of similar age from Nature Neuroscience
#2
of 69 outputs
Altmetric has tracked 24,891,087 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,533 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 437,241 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.