A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear

Overview of attention for article published in Nature Biotechnology, February 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#5 of 3,814)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
94 news outlets
blogs
4 blogs
twitter
80 tweeters
facebook
7 Facebook pages

Readers on

mendeley
44 Mendeley
Title
A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear
Published in
Nature Biotechnology, February 2017
DOI 10.1038/nbt.3781
Pubmed ID
Authors

Lukas D Landegger, Bifeng Pan, Charles Askew, Sarah J Wassmer, Sarah D Gluck, Alice Galvin, Ruth Taylor, Andrew Forge, Konstantina M Stankovic, Jeffrey R Holt, Luk H Vandenberghe, Landegger, Lukas D, Pan, Bifeng, Askew, Charles, Wassmer, Sarah J, Gluck, Sarah D, Galvin, Alice, Taylor, Ruth, Forge, Andrew, Stankovic, Konstantina M, Holt, Jeffrey R, Vandenberghe, Luk H

Abstract

Efforts to develop gene therapies for hearing loss have been hampered by the lack of safe, efficient, and clinically relevant delivery modalities. Here we demonstrate the safety and efficiency of Anc80L65, a rationally designed synthetic vector, for transgene delivery to the mouse cochlea. Ex vivo transduction of mouse organotypic explants identified Anc80L65 from a set of other adeno-associated virus (AAV) vectors as a potent vector for the cochlear cell targets. Round window membrane injection resulted in highly efficient transduction of inner and outer hair cells in mice, a substantial improvement over conventional AAV vectors. Anc80L65 round window injection was well tolerated, as indicated by sensory cell function, hearing and vestibular function, and immunologic parameters. The ability of Anc80L65 to target outer hair cells at high rates, a requirement for restoration of complex auditory function, may enable future gene therapies for hearing and balance disorders.

Twitter Demographics

The data shown below were collected from the profiles of 80 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 32%
Researcher 8 18%
Student > Bachelor 7 16%
Professor > Associate Professor 4 9%
Student > Master 4 9%
Other 7 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 43%
Biochemistry, Genetics and Molecular Biology 10 23%
Medicine and Dentistry 7 16%
Chemical Engineering 2 5%
Immunology and Microbiology 2 5%
Other 4 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 812. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2017.
All research outputs
#2,184
of 7,430,852 outputs
Outputs from Nature Biotechnology
#5
of 3,814 outputs
Outputs of similar age
#240
of 201,753 outputs
Outputs of similar age from Nature Biotechnology
#1
of 97 outputs
Altmetric has tracked 7,430,852 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,814 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 201,753 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.