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Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

Overview of attention for article published in Nature Genetics, January 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

news
13 news outlets
blogs
1 blog
twitter
97 X users
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

dimensions_citation
362 Dimensions

Readers on

mendeley
525 Mendeley
citeulike
1 CiteULike
Title
Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis
Published in
Nature Genetics, January 2017
DOI 10.1038/ng.3753
Pubmed ID
Authors

Oliver G McDonald, Xin Li, Tyler Saunders, Rakel Tryggvadottir, Samantha J Mentch, Marc O Warmoes, Anna E Word, Alessandro Carrer, Tal H Salz, Sonoko Natsume, Kimberly M Stauffer, Alvin Makohon-Moore, Yi Zhong, Hao Wu, Kathryn E Wellen, Jason W Locasale, Christine A Iacobuzio-Donahue, Andrew P Feinberg

Abstract

During the progression of pancreatic ductal adenocarcinoma (PDAC), heterogeneous subclonal populations emerge that drive primary tumor growth, regional spread, distant metastasis, and patient death. However, the genetics of metastases largely reflects that of the primary tumor in untreated patients, and PDAC driver mutations are shared by all subclones. This raises the possibility that an epigenetic process might operate during metastasis. Here we report large-scale reprogramming of chromatin modifications during the natural evolution of distant metastasis. Changes were targeted to thousands of large chromatin domains across the genome that collectively specified malignant traits, including euchromatin and large organized chromatin histone H3 lysine 9 (H3K9)-modified (LOCK) heterochromatin. Remarkably, distant metastases co-evolved a dependence on the oxidative branch of the pentose phosphate pathway (oxPPP), and oxPPP inhibition selectively reversed reprogrammed chromatin, malignant gene expression programs, and tumorigenesis. These findings suggest a model whereby linked metabolic-epigenetic programs are selected for enhanced tumorigenic fitness during the evolution of distant metastasis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 97 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 525 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 <1%
United Kingdom 3 <1%
Italy 1 <1%
Germany 1 <1%
Canada 1 <1%
Korea, Republic of 1 <1%
Unknown 513 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 142 27%
Researcher 92 18%
Student > Bachelor 47 9%
Student > Master 43 8%
Student > Doctoral Student 31 6%
Other 77 15%
Unknown 93 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 197 38%
Agricultural and Biological Sciences 101 19%
Medicine and Dentistry 59 11%
Immunology and Microbiology 15 3%
Pharmacology, Toxicology and Pharmaceutical Science 9 2%
Other 44 8%
Unknown 100 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 148. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2022.
All research outputs
#280,491
of 25,559,053 outputs
Outputs from Nature Genetics
#508
of 7,592 outputs
Outputs of similar age
#6,006
of 423,292 outputs
Outputs of similar age from Nature Genetics
#15
of 72 outputs
Altmetric has tracked 25,559,053 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,592 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.0. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 423,292 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.