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Persistent infection with Crohn’s disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis

Overview of attention for article published in Nature Communications, June 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

Mentioned by

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1 news outlet
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9 X users
googleplus
2 Google+ users

Citations

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141 Dimensions

Readers on

mendeley
197 Mendeley
Title
Persistent infection with Crohn’s disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis
Published in
Nature Communications, June 2013
DOI 10.1038/ncomms2957
Pubmed ID
Authors

Cherrie-Lee N. Small, Sarah A. Reid-Yu, Joseph B. McPhee, Brian K. Coombes

Abstract

Crohn's disease is a chronic inflammatory condition of the gastrointestinal tract in which alterations to the bacterial community contribute to disease. Adherent-invasive Escherichia coli are associated with human Crohn's disease; however, their role in intestinal immunopathology is unclear because of the lack of an animal model compatible with chronic timescales. Here we establish chronic adherent-invasive Escherichia coli infection in streptomycin-treated conventional mice (CD1, DBA/2, C3H, 129e and C57BL/6), enabling the study of host response and immunopathology. Adherent-invasive Escherichia coli induces an active T-helper 17 response, heightened levels of proinflammatory cytokines and fibrotic growth factors, with transmural inflammation and fibrosis. Depletion of CD8+ T cells increases caecal bacterial load, pathology and intestinal fibrosis in C57BL/6 mice, suggesting a protective role. Our findings provide evidence that chronic adherent-invasive Escherichia coli infections result in immunopathology similar to that seen in Crohn's disease. With this model, research into the host and bacterial genetics associated with adherent-invasive Escherichia coli-induced disease becomes more widely accessible.

X Demographics

X Demographics

The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 197 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 2%
United Kingdom 4 2%
Netherlands 1 <1%
Russia 1 <1%
China 1 <1%
Unknown 186 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 38 19%
Student > Ph. D. Student 36 18%
Researcher 32 16%
Student > Master 23 12%
Other 7 4%
Other 23 12%
Unknown 38 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 61 31%
Biochemistry, Genetics and Molecular Biology 35 18%
Immunology and Microbiology 30 15%
Medicine and Dentistry 14 7%
Chemistry 4 2%
Other 9 5%
Unknown 44 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2017.
All research outputs
#1,797,615
of 22,711,645 outputs
Outputs from Nature Communications
#22,466
of 46,752 outputs
Outputs of similar age
#16,308
of 197,423 outputs
Outputs of similar age from Nature Communications
#124
of 341 outputs
Altmetric has tracked 22,711,645 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 46,752 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,423 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 341 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.