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Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids

Overview of attention for article published in Nature Communications, May 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
6 news outlets
blogs
1 blog
twitter
11 X users
patent
12 patents
facebook
3 Facebook pages

Citations

dimensions_citation
302 Dimensions

Readers on

mendeley
260 Mendeley
Title
Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids
Published in
Nature Communications, May 2013
DOI 10.1038/ncomms2886
Pubmed ID
Authors

Qilong Wang, Xiaoying Zhuang, Jingyao Mu, Zhong-Bin Deng, Hong Jiang, Lifeng Zhang, Xiaoyu Xiang, Baomei Wang, Jun Yan, Donald Miller, Huang-Ge Zhang

Abstract

Although the use of nanotechnology for the delivery of a wide range of medical treatments has potential to reduce adverse effects associated with drug therapy, tissue-specific delivery remains challenging. Here we show that nanoparticles made of grapefruit-derived lipids, which we call grapefruit-derived nanovectors, can deliver chemotherapeutic agents, short interfering RNA, DNA expression vectors and proteins to different types of cells. We demonstrate the in vivo targeting specificity of grapefruit-derived nanovectors by co-delivering therapeutic agents with folic acid, which in turn leads to significantly increasing targeting efficiency to cells expressing folate receptors. The therapeutic potential of grapefruit-derived nanovectors was further demonstrated by enhancing the chemotherapeutic inhibition of tumour growth in two tumour animal models. Grapefruit-derived nanovectors are less toxic than nanoparticles made of synthetic lipids and, when injected intravenously into pregnant mice, do not pass the placental barrier, suggesting that they may be a useful tool for drug delivery.

X Demographics

X Demographics

The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 260 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Japan 1 <1%
Portugal 1 <1%
Russia 1 <1%
Unknown 256 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 58 22%
Researcher 38 15%
Student > Master 33 13%
Student > Doctoral Student 15 6%
Student > Bachelor 15 6%
Other 29 11%
Unknown 72 28%
Readers by discipline Count As %
Agricultural and Biological Sciences 43 17%
Biochemistry, Genetics and Molecular Biology 38 15%
Medicine and Dentistry 14 5%
Pharmacology, Toxicology and Pharmaceutical Science 14 5%
Chemistry 13 5%
Other 48 18%
Unknown 90 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 68. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2023.
All research outputs
#625,821
of 25,321,938 outputs
Outputs from Nature Communications
#10,819
of 56,157 outputs
Outputs of similar age
#4,260
of 201,362 outputs
Outputs of similar age from Nature Communications
#37
of 365 outputs
Altmetric has tracked 25,321,938 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 56,157 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.8. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 201,362 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 365 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.