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Neutralization mechanism of a highly potent antibody against Zika virus

Overview of attention for article published in Nature Communications, November 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
25 news outlets
blogs
2 blogs
twitter
28 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
68 Dimensions

Readers on

mendeley
149 Mendeley
Title
Neutralization mechanism of a highly potent antibody against Zika virus
Published in
Nature Communications, November 2016
DOI 10.1038/ncomms13679
Pubmed ID
Authors

Shuijun Zhang, Victor A. Kostyuchenko, Thiam-Seng Ng, Xin-Ni Lim, Justin S. G. Ooi, Sebastian Lambert, Ter Yong Tan, Douglas G. Widman, Jian Shi, Ralph S. Baric, Shee-Mei Lok

Abstract

The rapid spread of Zika virus (ZIKV), which causes microcephaly and Guillain-Barré syndrome, signals an urgency to identify therapeutics. Recent efforts to rescreen dengue virus human antibodies for ZIKV cross-neutralization activity showed antibody C10 as one of the most potent. To investigate the ability of the antibody to block fusion, we determined the cryoEM structures of the C10-ZIKV complex at pH levels mimicking the extracellular (pH8.0), early (pH6.5) and late endosomal (pH5.0) environments. The 4.0 Å resolution pH8.0 complex structure shows that the antibody binds to E proteins residues at the intra-dimer interface, and the virus quaternary structure-dependent inter-dimer and inter-raft interfaces. At pH6.5, antibody C10 locks all virus surface E proteins, and at pH5.0, it locks the E protein raft structure, suggesting that it prevents the structural rearrangement of the E proteins during the fusion event-a vital step for infection. This suggests antibody C10 could be a good therapeutic candidate.

Twitter Demographics

The data shown below were collected from the profiles of 28 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 <1%
Unknown 148 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 28 19%
Student > Ph. D. Student 27 18%
Student > Master 27 18%
Student > Bachelor 25 17%
Student > Doctoral Student 5 3%
Other 19 13%
Unknown 18 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 38 26%
Immunology and Microbiology 24 16%
Agricultural and Biological Sciences 22 15%
Medicine and Dentistry 11 7%
Chemistry 8 5%
Other 22 15%
Unknown 24 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 208. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2017.
All research outputs
#107,812
of 18,468,417 outputs
Outputs from Nature Communications
#1,568
of 36,635 outputs
Outputs of similar age
#3,907
of 403,299 outputs
Outputs of similar age from Nature Communications
#168
of 2,824 outputs
Altmetric has tracked 18,468,417 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 36,635 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 53.1. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 403,299 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 2,824 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.