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Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk

Overview of attention for article published in Nature Communications, November 2016
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3 tweeters

Citations

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52 Mendeley
Title
Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk
Published in
Nature Communications, November 2016
DOI 10.1038/ncomms13420
Pubmed ID
Authors

Albert Guskov, Sonja Jensen, Ignacio Faustino, Siewert J. Marrink, Dirk Jan Slotboom

Abstract

Glutamate transporters catalyse the thermodynamically unfavourable transport of anionic amino acids across the cell membrane by coupling it to the downhill transport of cations. This coupling mechanism is still poorly understood, in part because the available crystal structures of these transporters are of relatively low resolution. Here we solve crystal structures of the archaeal transporter GltTk in the presence and absence of aspartate and use molecular dynamics simulations and binding assays to show how strict coupling between the binding of three sodium ions and aspartate takes place.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Unknown 51 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 42%
Researcher 9 17%
Student > Master 7 13%
Student > Bachelor 5 10%
Professor 1 2%
Other 4 8%
Unknown 4 8%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 24 46%
Agricultural and Biological Sciences 10 19%
Chemistry 8 15%
Physics and Astronomy 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 1 2%
Unknown 4 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2018.
All research outputs
#8,486,787
of 13,532,333 outputs
Outputs from Nature Communications
#20,837
of 24,323 outputs
Outputs of similar age
#161,820
of 286,697 outputs
Outputs of similar age from Nature Communications
#2,572
of 3,020 outputs
Altmetric has tracked 13,532,333 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,323 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 47.2. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,697 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3,020 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.