| Title |
Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk
|
|---|---|
| Published in |
Nature Communications, November 2016
|
| DOI | 10.1038/ncomms13420 |
| Pubmed ID | |
| Authors |
Albert Guskov, Sonja Jensen, Ignacio Faustino, Siewert J. Marrink, Dirk Jan Slotboom |
| Abstract |
Glutamate transporters catalyse the thermodynamically unfavourable transport of anionic amino acids across the cell membrane by coupling it to the downhill transport of cations. This coupling mechanism is still poorly understood, in part because the available crystal structures of these transporters are of relatively low resolution. Here we solve crystal structures of the archaeal transporter GltTk in the presence and absence of aspartate and use molecular dynamics simulations and binding assays to show how strict coupling between the binding of three sodium ions and aspartate takes place. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Unknown | 67 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 37% |
| Student > Master | 13 | 19% |
| Researcher | 8 | 12% |
| Student > Bachelor | 4 | 6% |
| Professor | 2 | 3% |
| Other | 6 | 9% |
| Unknown | 10 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 29 | 43% |
| Agricultural and Biological Sciences | 10 | 15% |
| Chemistry | 9 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
| Physics and Astronomy | 3 | 4% |
| Other | 3 | 4% |
| Unknown | 9 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2018.
All research outputs
#18,294,766
of 23,498,099 outputs
Outputs from Nature Communications
#44,926
of 48,767 outputs
Outputs of similar age
#225,947
of 314,632 outputs
Outputs of similar age from Nature Communications
#873
of 961 outputs
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