| Title |
Telomeres shorten at equivalent rates in somatic tissues of adults
|
|---|---|
| Published in |
Nature Communications, March 2013
|
| DOI | 10.1038/ncomms2602 |
| Pubmed ID | |
| Authors |
Lily Daniali, Athanase Benetos, Ezra Susser, Jeremy D. Kark, Carlos Labat, Masayuki Kimura, Kunj K. Desai, Mark Granick, Abraham Aviv |
| Abstract |
Telomere shortening in somatic tissues largely reflects stem cell replication. Previous human studies of telomere attrition were predominantly conducted on leukocytes. However, findings in leukocytes cannot be generalized to other tissues. Here we measure telomere length in leukocytes, skeletal muscle, skin and subcutaneous fat of 87 adults (aged 19-77 years). Telomeres are longest in muscle and shortest in leukocytes, yet are strongly correlated between tissues. Notably, the rates of telomere shortening are similar in the four tissues. We infer from these findings that differences in telomere length between proliferative (blood and skin) and minimally proliferative tissues (muscle and fat) are established during early life, and that in adulthood, stem cells of the four tissues replicate at a similar rate. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 40% |
| Mexico | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 323 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 1% |
| United States | 2 | <1% |
| Portugal | 1 | <1% |
| Canada | 1 | <1% |
| Netherlands | 1 | <1% |
| Spain | 1 | <1% |
| Romania | 1 | <1% |
| Unknown | 312 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 77 | 24% |
| Researcher | 49 | 15% |
| Student > Master | 37 | 11% |
| Student > Bachelor | 27 | 8% |
| Other | 18 | 6% |
| Other | 46 | 14% |
| Unknown | 69 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 84 | 26% |
| Biochemistry, Genetics and Molecular Biology | 57 | 18% |
| Medicine and Dentistry | 40 | 12% |
| Psychology | 17 | 5% |
| Social Sciences | 7 | 2% |
| Other | 39 | 12% |
| Unknown | 79 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2024.
All research outputs
#3,072,492
of 26,017,215 outputs
Outputs from Nature Communications
#32,297
of 58,133 outputs
Outputs of similar age
#24,772
of 214,321 outputs
Outputs of similar age from Nature Communications
#127
of 319 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 58,133 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 214,321 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 319 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.