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DNA methylation of distal regulatory sites characterizes dysregulation of cancer genes

Overview of attention for article published in Genome Biology, March 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

blogs
1 blog
twitter
21 X users
patent
3 patents

Citations

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292 Dimensions

Readers on

mendeley
345 Mendeley
citeulike
6 CiteULike
Title
DNA methylation of distal regulatory sites characterizes dysregulation of cancer genes
Published in
Genome Biology, March 2013
DOI 10.1186/gb-2013-14-3-r21
Pubmed ID
Authors

Dvir Aran, Sivan Sabato, Asaf Hellman

Abstract

BACKGROUND: Abnormal epigenetic marking is well documented in gene promoters of cancer cells, but the study of distal regulatory siteshas lagged behind.We performed a systematic analysis of DNA methylation sites connected with gene expression profilesacross normal and cancerous human genomes. RESULTS: Utilizing methylation and expression data in 58 cell types, we developed a model for methylation-expression relationships in gene promoters and extrapolated it to the genome. We mapped numerous sites at whichDNA methylation was associated with expression of distal genes. These sites bind transcription factors in a methylation-dependent manner, and carry the chromatin marks of a particular class of transcriptional enhancers. In contrast to the traditional model of one enhancer site per cell type, we found that single enhancer sites may define gradients of expression levels across many different cell types. Strikingly, the identified sites were drastically altered in cancers: hypomethylated enhancer sites associated withupregulation of cancer-related genes and hypermethylated sites with downregulation. Moreover, the association between enhancer methylation and gene deregulation in cancerwas significantly stronger than the association of promoter methylationwith gene deregulation. CONCLUSIONS: Methylation of distal regulatory sites is closely related to gene expression levels across the genome. Single enhancers may modulate ranges of cell-specific transcription levels, from constantlyopen promoters. In contrast to the remote relationships between promoter methylation and gene dysregulation in cancer, altered methylation of enhancer sites is closely related to gene expression profiles of transformed cells.

X Demographics

X Demographics

The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 345 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 7 2%
France 1 <1%
Norway 1 <1%
Ireland 1 <1%
Germany 1 <1%
Belgium 1 <1%
United Kingdom 1 <1%
Spain 1 <1%
Denmark 1 <1%
Other 0 0%
Unknown 330 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 87 25%
Researcher 80 23%
Student > Master 42 12%
Student > Bachelor 31 9%
Student > Doctoral Student 18 5%
Other 45 13%
Unknown 42 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 130 38%
Biochemistry, Genetics and Molecular Biology 97 28%
Computer Science 21 6%
Medicine and Dentistry 18 5%
Chemistry 7 2%
Other 21 6%
Unknown 51 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2023.
All research outputs
#1,590,954
of 25,374,917 outputs
Outputs from Genome Biology
#1,303
of 4,467 outputs
Outputs of similar age
#12,301
of 208,479 outputs
Outputs of similar age from Genome Biology
#19
of 45 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,479 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.