RT @PappulabWashU: Hao Jiang's paper is a must-read. A core IDR in UTX drives condensation, & is essential for tumor-suppression activity.…
RT @PappulabWashU: Hao Jiang's paper is a must-read. A core IDR in UTX drives condensation, & is essential for tumor-suppression activity.…
UTX condensation underlies its tumour-suppressive activity https://t.co/SPqUc5bQge
RT @PappulabWashU: Hao Jiang's paper is a must-read. A core IDR in UTX drives condensation, & is essential for tumor-suppression activity.…
RT @PappulabWashU: Hao Jiang's paper is a must-read. A core IDR in UTX drives condensation, & is essential for tumor-suppression activity.…
RT @PappulabWashU: Hao Jiang's paper is a must-read. A core IDR in UTX drives condensation, & is essential for tumor-suppression activity.…
RT @PappulabWashU: Hao Jiang's paper is a must-read. A core IDR in UTX drives condensation, & is essential for tumor-suppression activity.…
RT @PappulabWashU: Hao Jiang's paper is a must-read. A core IDR in UTX drives condensation, & is essential for tumor-suppression activity.…
RT @PappulabWashU: Hao Jiang's paper is a must-read. A core IDR in UTX drives condensation, & is essential for tumor-suppression activity.…
RT @PappulabWashU: Hao Jiang's paper is a must-read. A core IDR in UTX drives condensation, & is essential for tumor-suppression activity.…
RT @PappulabWashU: Hao Jiang's paper is a must-read. A core IDR in UTX drives condensation, & is essential for tumor-suppression activity.…
RT @PappulabWashU: Hao Jiang's paper is a must-read. A core IDR in UTX drives condensation, & is essential for tumor-suppression activity.…
Hao Jiang's paper is a must-read. A core IDR in UTX drives condensation, & is essential for tumor-suppression activity. The cIDR works with the TPR domain, which orchestrates the tumour-suppressive gene-expression program". Separation of functions!! ht
One of these observations that intuitively feels wrong, but totally makes sense when you get a chance to think about it!
Hao told us how the IDR of the tumor suppressor UTX drives LLPS. The biology tolerates replacement of the whole IDR with an unrelated sequence, but is also sensitive to single point mutations. 🤯 Hao links this to the need for material properties. https
UTX condensation underlies its tumour-suppressive activity https://t.co/KMGoMelCqz
UTX condensation underlies its tumour-suppressive activity | Nature https://t.co/BBExFMHVVM
RT @jyasuda1: UTXは別名をKDM6Aといい、がん遺伝子パネル検査では結構な頻度で変異を示すがん抑制遺伝子だが、本来の活性と信じられているヒストンメチル化活性と変異が関連しないらしい。実はこれもクロマチンでの相分離を誘導することが主たる機能という論文。Nature…
RT @jyasuda1: UTXは別名をKDM6Aといい、がん遺伝子パネル検査では結構な頻度で変異を示すがん抑制遺伝子だが、本来の活性と信じられているヒストンメチル化活性と変異が関連しないらしい。実はこれもクロマチンでの相分離を誘導することが主たる機能という論文。Nature…
RT @jyasuda1: UTXは別名をKDM6Aといい、がん遺伝子パネル検査では結構な頻度で変異を示すがん抑制遺伝子だが、本来の活性と信じられているヒストンメチル化活性と変異が関連しないらしい。実はこれもクロマチンでの相分離を誘導することが主たる機能という論文。Nature…
RT @jyasuda1: UTXは別名をKDM6Aといい、がん遺伝子パネル検査では結構な頻度で変異を示すがん抑制遺伝子だが、本来の活性と信じられているヒストンメチル化活性と変異が関連しないらしい。実はこれもクロマチンでの相分離を誘導することが主たる機能という論文。Nature…
RT @jyasuda1: UTXは別名をKDM6Aといい、がん遺伝子パネル検査では結構な頻度で変異を示すがん抑制遺伝子だが、本来の活性と信じられているヒストンメチル化活性と変異が関連しないらしい。実はこれもクロマチンでの相分離を誘導することが主たる機能という論文。Nature…
RT @jyasuda1: UTXは別名をKDM6Aといい、がん遺伝子パネル検査では結構な頻度で変異を示すがん抑制遺伝子だが、本来の活性と信じられているヒストンメチル化活性と変異が関連しないらしい。実はこれもクロマチンでの相分離を誘導することが主たる機能という論文。Nature…
RT @jyasuda1: UTXは別名をKDM6Aといい、がん遺伝子パネル検査では結構な頻度で変異を示すがん抑制遺伝子だが、本来の活性と信じられているヒストンメチル化活性と変異が関連しないらしい。実はこれもクロマチンでの相分離を誘導することが主たる機能という論文。Nature…
RT @jyasuda1: UTXは別名をKDM6Aといい、がん遺伝子パネル検査では結構な頻度で変異を示すがん抑制遺伝子だが、本来の活性と信じられているヒストンメチル化活性と変異が関連しないらしい。実はこれもクロマチンでの相分離を誘導することが主たる機能という論文。Nature…
RT @jyasuda1: UTXは別名をKDM6Aといい、がん遺伝子パネル検査では結構な頻度で変異を示すがん抑制遺伝子だが、本来の活性と信じられているヒストンメチル化活性と変異が関連しないらしい。実はこれもクロマチンでの相分離を誘導することが主たる機能という論文。Nature…
UTXは別名をKDM6Aといい、がん遺伝子パネル検査では結構な頻度で変異を示すがん抑制遺伝子だが、本来の活性と信じられているヒストンメチル化活性と変異が関連しないらしい。実はこれもクロマチンでの相分離を誘導することが主たる機能という論文。Nature誌。 https://t.co/ltVYJwTbms
RT @giacomo_cavalli: "UTX condensation underlies its #tumour-suppressive activity". Possibly, phase separation provides a way to compartmen…
Chromatin regulation of UTX protein condenstates https://t.co/SPqUc5sTie
UTX condensation underlies its tumour-suppressive activity https://t.co/g2vESSF5bV https://t.co/5uPXpt5Vzs
UTX condensation underlies its tumour-suppressive activity https://t.co/qm0HCooSrO
RT @EllisLab_: UTX condensation underlies its tumour-suppressive activity | Nature https://t.co/uAwOVkgPFZ
UTX condensation underlies its tumour-suppressive activity | Nature https://t.co/uAwOVkgPFZ
Mechanism underlying sex differences in brain function..... https://t.co/5wcUBQKiiw
It's the time to screen up all intrinsically disordered regions of epigenetic modifiers. Here comes a nice piece of UTX histone demethylase condensation underlies its tumour-suppressive activity.
UTX condensation underlies its tumour-suppressive activity https://t.co/o95zXkaz7S https://t.co/srIP8Oz22a
delighted to share our recent work with Hao Jiang and collaborators published in @Nature showing that UTX regulates chromatin through phase separation @ZhenjiaWang @UVACPHG @uvavpr @UVA https://t.co/NwZTOW8Pvn
📫 #CancerNaturePortfolio research @nature: UTX condensation underlies its tumour-suppressive activity, by Bi Shi et al., Hao Jiang @MedicineUVA. https://t.co/gx9SdVrrxj #LLPS #phaseseparation #tumorsuppression 🦀 Check all new content: https://t.co/Nc8u
RT @michelledigman: Super excited to share this work with Hao Jiang & Collaborators that was published a day ago in Nature. UTX condensatio…
RT @michelledigman: Super excited to share this work with Hao Jiang & Collaborators that was published a day ago in Nature. UTX condensatio…
Super excited to share this work with Hao Jiang & Collaborators that was published a day ago in Nature. UTX condensation underlies its tumour-suppressive activity https://t.co/EORktPdV9N
UTX condensation underlies its tumoursuppressive activity null https://t.co/m9kyFsDMiO #DTHSTR
RT @ShorterLab: UTX condensation underlies its tumour-suppressive activity: https://t.co/EJ8F97nM3D
RT @ShorterLab: UTX condensation underlies its tumour-suppressive activity: https://t.co/EJ8F97nM3D
UTX condensation underlies its tumour-suppressive activity: https://t.co/EJ8F97nM3D
UTX condensation underlies its tumour-suppressive activity https://t.co/1j3kGTaWtX
UTX condensation underlies its tumour-suppressive activity https://t.co/1GRwBaQSkw https://t.co/6mNxtLlsVC | #research #manuscripts @nature